Pardes Biosciences, Inc.

Kinnate Biopharma Inc.

Other

Khora Spv 1, LLC

Lee D Arnold

Stephen W Kaldor

Toufike Kanouni

Andy Jennings

Walter Keung

Eric A Murphy

John S Tyhonas

Robert Steven Kania

Jason M Cox

John Tyhonas

Robert Kania

Provided herein are heteroaryl inhibitors of fibroblast growth factor receptor kinases, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Inhibitors of fibroblast growth factor receptor kinases

The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

Inhibitors of cysteine proteases and methods of use thereof

Provided herein are heteroaryl inhibitors of receptor tyrosine kinase effector (RAF), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of disease.

Inhibitors of RAF kinases

The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease. 

Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Inhibitors of cyclin-dependent kinases

The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease. Exemplary compounds provided include Formula II-I, where R, Rare provided herein: 

Method and apparatus for converting the kinetic energy of a moving fluid stream into useful work by using a cascade of thin aero or hydro foils positioned therein. The foils may be provided with at least two degrees of freedom and adjacent foils move out of phase. The foils are subjected to fluid induced oscillations known as flutter. Barriers (,) may be positioned upstream, above, or at sides of the apparatus for increasing efficiency by increasing the fluid velocity. A system of flywheels (,) are used to increase inertia of the foils and are particularly useful with hydrofoils. A cascade of aero or hydro foils may be mechanically oscillated to transfer energy to a fluid.

Extraction of energy from flowing fluids

There is disclosed a method and apparatus for converting the kinetic energy of a moving fluid stream into useful work by means of a cascade of thin airfoils positioned therein. In one embodiment, the airfoils are provided with at least two degrees of freedom and adjacent airfoils are movable out of phase. The airfoils are subjected to the aerodynamically induced oscillations caused by the aeroelastic phenomenon known as flutter and the oscillatory movement is then harnessed to do useful work. In an alternate embodiment, a cascade of airfoils is mechanically oscillated within a moving fluid stream to increase the propulsion of the fluid. Where the fluid is a liquid, the cascade includes a plurality of hydrofoils.

Growing community of inventors

Rancho Santa Fe, CA, United States of America

Lee D Arnold