Vybion, Inc.

Lee Alan Henderson

Irene Alexandra Amaro

Leo B Kriksunov

Geoffrey Wheelock

Compositions and methods of use are provided for intrabodies that bind and alter the effects of poly-glutamate protein aggregation in poly-glutamate associated diseases, such as in Huntington's disease. Intrabodies are provided that prevent poly-glutamate aggregation, gene dysregulation, and negative effects of Huntington's disease.

Single chain intrabodies that alter Huntingtin mutant degradation

Single chain intrabodies that alter huntingtin mutant degradation

A method for assaying a biological sample includes forming sensitized microcapsules filled with unique oligomarkers, capturing sensitized microcapsules in the presence of analytes, releasing oligomarkers from microcapsules and detecting and measuring oligomarkers to detect and quantify presence of analyte in biological sample. Using encapsulated oligomarkers provides for an amplified high sensitivity assay and using plurality of oligomarker types provides for a multiplexed assay.

Growing community of inventors

Ithaca, NY, United States of America

Lee Alan Henderson