Baxter International Inc.

Baxter Healthcare Sa

Medline Industries, Inc.

Baxter Travenol Laboratories, Inc.

Lecon Woo

Michael T K Ling

Michael T Ling

Chuan Qin

Dean G Laurin

Larry A Rosenbaum

Yuan-pang Samuel Ding

William Anderson

Patrick T Ryan

Birendra K Lal

Gregg Nebgen

Stanley Westphal

Angeles Lillian Buan

Joseph P Hoppesch

Denise S Hayward

Donna L Rostron

Susan R Mizener

Ying-Cheng Lo

Yuanpang Samuel Ding

Sherwin S Shang

Tahua Yang

Patrick R Balteau

Craig L Sandford

Shmuel Sternberg

Atul R Khare

Yuan Pang Samuel Ding

Eddie K Chan

Yuan Pang Ding

Robin Gail Pauley

Eric J Henaut

Craig Sanford

Sandra Wade

Daniel R Boggs

Sidney T Smith

David V Bacehowski

Ton That Hai

Ketan N Shah

Hsinjin E Yang

Rosa Yeh

William S Hurst

Indrajit T Patel

Hugh M Forman

James G Bender

Stephen L Smith

Algirdas J Bindokas

Robert A Clarke

Dustin Christopher Cawthon

Kent Lane Lurvey

Sivaramakrishnan Krishnamoorthy

Mark Nordhaus

Vadim V Krongauz

Scott D Edwards

Michael Tung-Kiung Ling

Dale R Severs

William D Johnston

Henk P Blom

Shaye-Wen Shang

Martin F Miller

William Kolanko

Julian Breillatt

Byron Gleason

William S Hoerle

Franco Peluso

Robert Wojnarowski

Ying Lo

Lisa S Walsh

Thomas D Hiller

Joyce Silvestri

Andrew D Aswad

Lillian A Buan

Ashok K Khanna

Alexander Savitski

Nicklaus J Kirichkow

Kenneth Glen Suh

Marc C Bellotti

James H Brauker

Francesco Peluso

Julian P Breillatt, Jr

Deanna J Nelson

Sumner A Barenberg

Randy K Murphey

Randolph H Watkins

Samuel Ding

Michael W Scharf

Rafael A Castellanos

Sarah Louise Corbin

Lillian G Zakarija

Varsha Kalyankar

Eric P Loh

Keith M K Anderson

Naomi L Weinless

Robin Peters

Richard Mennenoh

George Dillon

Dale Pennington

Colleen S Cramer

Joel Warren

H&eacute;naut J Eric

John O'Connor

Jerry D Bartos

A liquid excipient is added to a lock solution formulation containing a lower alcohol and an anti-coagulant, antibiotic, and/or anti-microbial, such as the ethanol and tri-sodium citrate lock solution formulation, to prevent citrate from crystallizing in catheters made from silicone. The locking solution could include a liquid excipient, such as glycerol, polysorbate-20, or polyethylene glycol (PEG)-400, along with a lower alcohol, such as ethanol, and an anti-coagulant, such as tri-sodium citrate, antibiotic, and/or anti-microbial.

Catheter lock solution formulations

A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.

Medical fluid access device with antiseptic indicator

The present invention provides a flowable material container assembly having a membrane tube disposed coaxially within a port tube. The membrane tube has an outer layer, a core layer, and an inner layer. The outer layer is a blend of a polyolefin and a thermoplastic elastomer. The core layer is a blend of a polyolefin and a thermoplastic elastomer. The inner layer is a blend of a polyolefin, a radio frequency susceptible polymer, and a thermoplastic elastomer.

Port tube and closure composition, structure and assembly for a flowable material container

The present invention provides a flowable materials container. The container has a first sidewall and a second sidewall sealed together along a peripheral seam to define a fluid chamber. At least one sidewall is a film having at least one layer of blend of a first component selected from the group of: (1) ethylene and &#x3b1;-olefin copolymers having a density of less than about 0.915 g/cc, (2) ethylene copolymerized with lower alkyl acrylates, (3) ethylene copolymerized with lower alkyl substituted alkyl acrylates and (4) ionomers, the first component being present in an amount from about 99% to about 55% by weight of the blend, a second component in an amount by weight of the blend from about 45% to about 1% and consists of one or more polymers of the group: (1) propylene containing polymers, (2) polybutene polymers, (3) polymethylpentene polymers, (4) cyclic olefin containing polymers and (5) bridged polycyclic hydrocarbon containing polymers; and the film has a modulus of elasticity when measured in accordance with ASTM D882 of less than about 60,000 psi, an internal haze when measured in accordance with ASTM D1003 of less than about 25%, an internal adhesion ranking of greater than about 2, a sample creep at 120&#xb0; C. under 27 psi loading of less than or equal to 150% for a film having a thickness of from about 5 mils to about 15 mils, and the film can be heat sealed into a container having seals wherein the seals remain intact when the container is autoclaved at 121&#xb0; C. for one hour.

Containers and peelable seal containers of new non-PVC material

A polymer blend for fabricating medical products having a first 1,2 polybutadiene present from about 1% to about 99% by weight of the blend and having a first melting point temperature; and a second 1,2 polybutadiene present from about 1% to about 99% by weight of the blend and having a second melting point temperature higher than the first melting point temperature.

Method and process for enhancing properties and medical tubing performance in a polybutadiene material

The present invention provides a polymer blend for fabricating monolayer films or a layer within a multilayer film. The blend has a first component and a second component. The first component is selected from the group of: (1) an ethylene and &#x3b1;-olefin copolymer having a density of less than about 0.915 g/cc, (2) lower alkyl acrylates, (3) lower alkyl substituted alkyl acrylates and (4) ionomers. The first component should be present in an amount from about 99% to about 55% by weight of the blend. The second component in an amount by weight of the blend from 45% to about 1% and consists of one or more polymers of the group: (1) propylene containing polymers, (2) polybutene polymers, (3) polymethylpentene polymers, (4) cyclic olefin containing polymers and (5) bridged polycyclic hydrocarbon containing polymers. When the blend is fabricated into a film it has a modulus of elasticity when measured in accordance with ASTM D882 of less than about 60,000 psi, an internal haze when measured in accordance with ASTM D1003 of less than about 25%, an internal adhesion ranking of greater than about two, a sample creep at 120&#xb0; C. under 27 psi loading of less than or equal to 150% for a film having a thickness from about 5 mils to about 15 mils, and the film being capable or being heat sealed into a container having seals wherein the seals remain intact when the container is autoclaved at 121&#xb0; C. for one hour.

Autoclavable, non-adherent, heat sealable polymer blends for fabricating monolayer and multiple layered films

Multiple component polymer compositions for fabrication into articles. In particular, polymeric compositions comprising a heat resistant polymer; a radio frequency ('RF') susceptible polymer; a compatibilizing polymer; the composition having physical properties within a range a&#x3c;40,000 psi; b&#x3e;=70%; c&#x3c;30%; d&#x3e;1.0; e&#x3c;0.1%; f&#x3c;0.1%; g&#x3e;=0.05; h&#x3c;=60%; i=0; wherein: a is the mechanical modulus of the composition measured according to ASTM D-882; b is the percent recovery in length of the composition after an initial 20% deformation; c is the optical haze of the composition being 9 mils in thickness according to ASTM D-1003; d is the loss tangent of the composition at 1 Hz measured at melt processing temperatures; e is the elemental halogen content by weight of the composition; f is the low molecular weight water soluble fraction of the composition; g is the dielectric loss between 1 and 60 MHz and over temperatures of 25 to 250&#xb0; C. of the composition; h sample creep measured at 121&#xb0; C. for a 1 inch strip of the composition under 27 psi loading; and, i indicates the composition exhibits no strain whitening after being strained at moderate speeds of about 20 inches (50 cm) per minute to about 100% elongation (twice the original length) and the presence of strain whitening (indicated by 1) or lack thereof (indicated by 0) is noted.

Polymeric compositions for medical packaging and devices

The present invention provides a flowable material container closure assembly having a port tube and a membrane tube. The port tube (I) has a first layer and a second layer, (A) the first layer is a polymer blend and (B) the second layer is disposed coaxially within the first layer; and the membrane tube (II) is disposed coaxially within the port tube, the membrane tube has an outer layer, a core layer and an inner layer.

Port tube closure assembly

The present invention provides a multilayer film. The film has a first layer of a blend of a first component selected from the group of: (1) ethylene and a-olefin copolymers having a density of less than about 0.915 g/cc, (2) ethylene copolymerized with lower alkyl acrylates, (3) ethylene copolymerized with lower alkyl substituted alkyl acrylates and (4) ionomers, the first component being present in an amount from about 99% to about 55% by weight of the blend, a second component in an amount by weight of the blend from about 45% to about 1% and consists of one or more polymers of the group: (1) propylene containing polymers, (2) polybutene polymers, (3) polymethylpentene polymers, (4) cyclic olefin containing polymers and (5) bridged polycyclic hydrocarbon containing polymers; a second layer attached to the first layer; and the film has a modulus of elasticity when measured in accordance with ASTM D882 of less than about 60,000 psi, an internal haze when measured in accordance with ASTM D1003 of less than about 25%, an internal adhesion ranking of greater than about 2, a sample creep at 120&deg; C. under 27 psi loading of less than or equal to 150% for a film having a thickness of from about 5 mils to about 15 mils, and the film can be heat sealed into a container having seals wherein the seals remain intact when the container is autoclaved at 121 &deg; C. for one hour.

Multiple layer film of a new non-PVC material

The present invention provides a method for assembling a medical device using solvent bonding techniques. The method includes the steps of: (1) providing a first article of a polymer composition having (a) a first component of a homopolymer or copolymer obtained using monomers of cyclic olefin or a bridged polycyclic hydrocarbon, the first component being present in an amount from about 30% to about 100% by weight of the composition and (b) a second component from 0-70% by weight of the composition; (2) providing a second article of a material selected from the group of low crystallinity polymers; (3) applying a solvent to one of the first article or the second article to define an interface area; and (4) bonding the first article to the second article along the interface area.

Method for solvent bonding polyolefins

The present invention provides a method for using a polymeric cement to assemble medical devices. The method includes the steps of: (1) providing a first article of a low crystallinity polymer; (2) providing a second article of a low crystallinity polymer; (3) providing a cement composition having a first component of a cyclic olefin containing polymer or a bridged polycyclic hydrocarbon containing polymer and a second component of an effective amount of a solvent having a solubility parameter of less than about 20 (MPa) ; applying the cement composition to one of the first and second articles to define a bonding area; and (4) attaching the first article to the second article along the bonding area to fixedly attach the first article to the second article.

Solvent bonding method for polyolefin materials

A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a &ldquo;carrying&rdquo; mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber ( ) connected to a fluid flow through an inlet ( ) and an outlet ( ) on the belt chamber ( ). The belt chamber ( ) has a top surface ( ) and a bottom surface ( ). A radiation permeable plate ( ) is disposed adjacent the top surface ( ) of the belt chamber ( ) and is in contact with the belt chamber ( ). A radiation source ( ) is provided adjacent to the plate ( ) adjacent to a side opposite the belt chamber ( ). A belt ( ) having a plurality of flexible vanes ( ) is disposed adjacent the bottom surface ( ) of the belt chamber ( ) such that the vanes ( ) make contact with the belt chamber ( ). The belt is driven by a roller mechanism ( ) in the direction of the fluid flow. As the fluid flows through the belt chamber ( ), the flexible vanes ( ) provide a squeegee-like mechanism to move the fluid through the belt chamber ( ) in discrete packets ( ) defined by a pair of vanes ( ). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate ( ).

Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation

A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device ( ) comprises a radiation permeable cylindrical tube ( ) having a concentric cylindrical rotor ( ) disposed therein, thereby providing a thin gap ( ) therebetween. A top plate ( ) having a fluid outlet ( ) and a bottom plate ( ) having a fluid inlet ( ) seal the cylindrical tube ( ). The inlet ( ) and outlet ( ) are both in fluid communication with the thin gap ( ). A rotor shaft ( ) is disposed axially through the cylindrical rotor ( ) and is connected to a motor ( ). A pump provides fluid flow through the device ( ). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube ( ). As the fluid flows, the motor ( ) drives the rotor ( ) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube ( ) with the fluid closer to the rotor ( ).

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Libertyville, IL, United States of America

Lecon Woo