Aziende Chimiche Riunite Angelini Francesco A.c.r.a.f. S.p.a.

Istituto Ricerca Francesco Angelini S.p.a.

Other

Angelini Ricerche S.p.a. Societa'consortile

Leandro Baiocchi

Bruno Silvestrini

Valerio Cioli

Rosario Nicoletti

Mauro De Gregorio

Depalmo Galli Angeli

Method of preparing physiologically acceptable aqueous solutions, and solutions thus obtained

(S) or (R) enantiomer of a compound of formula: ##STR1## where Alk is an alkyl having from 1 to 3 carbon atoms, and an acid addition salt thereof with a physiologically acceptable acid.

Pharmacologically active enantiomers

Alkyl derivatives of trazodone endowed with pharmacological activity, pharmaceutical compositions containing them, process for preparing them and intermediate compounds useful in their preparation are disclosed.

Alkyl derivatives of trazodone with CNS activity

Glycogen polysaccharides substantially free of nitrogenous compounds and reducing sugars.

Glycogen polysaccharides

Alkyl derivatives of trazodone endowed with pharmacological activity, pharmaceutical compositions containing them, process for preparing them and intermediate compounds useful in their preparation.

A stable solid pharmaceutical composition for oral administration comprising dapiprazole or a physiologically acceptable acid salt thereof together with a pharmaceutically acceptable inert excipient and magnesium oxide as a degradation retarding agent is disclosed.

Solid pharmaceutical composition for oral administration containing

1-benzyl-3-hydroxymethyl-indazole compounds and derivatives

Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic

A method for removing a 1-chloro-3-dimethylaminopropane impurity from a benzydamine crude product which comprises steam distillation.

Manufacturing of benzydamine purification of benzydamine using steam

It was discovered that bendazac, or [(1-benzyl-1H-indazol-3-yl)oxy] acetic acid, when administered in a form suitable to obtain therapeutic tissue concentrations, determines a regression of cataract. It was demonstrated in particular, that the lysine salt of bendazac is well adapted for this use since it produces adequate tissue concentrations following both oral administration and topical application on the eye. The chemical and physical characteristics of this bendazac salt are described here together with the preparation techniques.

Bendazac treatment of cataract

Novel compounds selected from the group consisting of 2-[3-[4-(3-chloro-4-fluorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3 -a]pyridine-3(2H)-one (I) and from its non-toxic pharmaceutically acceptable salts possess analgesic, anti-convulsant and anti-depressant activities.

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Rome, Italy

Leandro Baiocchi