University System of Maryland

Other

Leah Tolosa

Govind Rao

Yordan Kostov

Xudong Ge

Douglas D Frey

Hung Lam

Steven Mitchell Falk

Joseph R Lakowicz

Michael Tolosa

David Burgenson

Rose Viscardi

Hyung Woo

Kevin Tran

Lisa Eichhorn

Virendra Singh

Lam Hung

Shayan Gholipour Borhani

Chandrashekar Gurramkonda

Manohar Pilli

A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.

System and method for production of on-demand proteins in a portable unit for point of care delivery

Systems and methods for determining an in vivo concentration of a small molecule substance of interest is provided that takes advantage of the semi-permeable nature of skin, which allows small molecules to passively diffuse through the skin and onto the skin surface. The systems and methods of the present invention allow for the collection of these small molecules that have passively diffused through the skin without skin disruption or breaking of the skin. The systems and methods of the present invention are noninvasive, painless and safe even for delicate newborns, and are particularly suited for the determination of blood glucose in newborns and infants in a noninvasive manner.

System and method for determining an in vivo concentration of a small molecule substance of interest in a noninvasive manner

A noninvasive remote parameter sensor and sensing method is provided that is particularly suited for the remote monitoring of skin temperature. The sensor and sensing method utilize luminescence-based sensors that are non-toxic and non-irritating to the skin. The sensor preferably utilizes one or more types of fluorophores that are embedded in a soft hydrogel. The sensor is illuminated with excitation light, and temperature is monitored by detecting and analyzing the emission light from the fluorophores. Because a soft hydrogel is used, the sensor can be gently wiped off the skin at the conclusion of temperature measurements.

Luminescence based noninvasive remote parameter sensor and sensing method

A non-invasive gas analyte sensing and monitoring system and method is provided that is particularly applicable to transcutaneous monitoring of arterial blood gases in a mammal. The system and method relies on diffusion of the analyte to be measured into a diffusion chamber and remote sensing of the analyte in the diffusion chamber using optical chemical sensors and associated optoelectronics.

Non-invasive analyte sensing system and method

A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein.

Microscale bioprocessing system and method for protein manufacturing

A fluorescence based sensor system that provides improved signal-to-noise over prior systems is provided. The system includes a fluorescence based sensing medium that is contained a recessed cavity with reflective sides that allow for more uniform excitation of the fluorescence based sensing medium by the excitation light.

Fluorescence based sensors utilizing a mirrored cavity

A system and method for measuring at least one bioprocess parameter utilizes a barrier that separates an external sensor from a culture medium. The barrier allows analytes to diffuse in and out of the culture vessel, thereby allowing the bioprocess parameter to be measured non-invasively by the external sensor.

Non-invasive sensing of bioprocess parameters

A low cost sensing system that can measure both chlorophyll concentration and turbidity is provided. The system is an optical system that utilizes at least three light sensors for measuring side-scattered and forward scattered light, as well as fluorescence. The system is able to take optical density measurements, steady state fluorescence measurements and maximum fluorescence measurements, and can be configured for wireless control and data transmission. The system may also be housed in one or more fluidtight housings so as to make it submersible.

Chlorophyll and turbidity sensor system

A protein sensing molecule is capable of binding an analyte in a sample. The protein sensing molecule includes a first detectable quality that changes in a concentration dependent manner when the protein sensing molecule is bound to the analyte. The protein sensing molecule also includes a second detectable quality that does not undergo substantial change when the protein sensing molecule is bound to the analyte. The protein sensing molecule may be used in methods for characterizing samples and may also be used in sensors.

Proteins, sensors, and methods of characterizing analytes using the same

Disclosed are methods and sensors for detecting the presence or concentration of an analyte in a sample, preferably a sugar such as glucose, which preferably utilizes a labeled engineered protein, or fragment thereof, that is capable of binding the analyte to be detected.

Growing community of inventors

Columbia, MD, United States of America

Leah Tolosa