Merck + Co., Inc.

Acer Therapeutics Inc.

Leah E Appel

Gaylen M Zentner

Joshua R Shockey

D Christopher Schelling

Process for preparing and film coating a dosage form. An intagliated dosage form core is produced by inscribing one or more areas on the surface of the dosage form core prior to coating. An aqueous dispersion of a polymeric coating is then applied to the intagliated dosage form core. When placed in an environment of use, the film coating within the circumscribed region of the dosage form surface is reproducibly expelled, leaving a coated core tablet with a predefined aperture in the coating which exposes a discrete portion of the core surface to the environment of use.

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Lawrence, KS, United States of America

Leah E Appel