Illumina Corporation

Lea Pickering

Kevin L Gunderson

Tarun Kumar Khurana

Boyan Boyanov

Matthew William Kellinger

Cyril Delattre

Kay Klausing

Christian Gloeckner

Liangliang Qiang

Cyril De Lattre

Presented herein are polymerase-linked nucleotides for improved distinguishing nucleotide sequences for different nucleic acid molecules. Also presented are methods and systems using the polymerase-linked nucleotides for improved distinguishing nucleotide sequences for different nucleic acid molecules.

Enzyme-linked nucleotides

Under one aspect, a composition includes a substrate; a first polynucleotide coupled to the substrate; a second polynucleotide hybridized to the first polynucleotide; and a catalyst coupled to a first nucleotide of the second polynucleotide, the catalyst being operable to cause a chemiluminogenic molecule to emit a photon. Under another aspect, a method includes providing a catalyst operable to cause a first chemiluminogenic molecule to emit a photon; providing a substrate; providing a first polynucleotide coupled to the substrate; hybridizing a second polynucleotide to the first polynucleotide; coupling a first quencher to a first nucleotide of the second polynucleotide; and inhibiting, by the first quencher, photon emission by the first chemiluminogenic molecule.

Compositions, systems, and methods for detecting the presence of polymer subunits using chemiluminescence

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Nr Saffron Walden, United Kingdom

Lea Pickering