Can-fite Biopharma Ltd.

Lea Madi

Pnina Fishman

Sara Bar-Yehuda

Sara Bar Yehuda

Inflammatory state in a subject is assayed by determining the level of expression of Aadenosine receptor (AAR) in white blood cells (WBC), e.g. circulating WBCs, from the subject. A high level of expression of AAR is indicative of an inflammatory state in the subject. This assay can be used for determining the severity of inflammation in a subject and monitoring the efficacy of anti-inflammatory treatment. Also, the level of expression may be used for selecting patients to receive an anti-inflammatory treatment that comprises an AAR agonist.

Biological marker for inflammation

Individuals suffering from multiple sclerosis may be treated by administration of an A3 adenosine receptor agonist (A3RAg), such as APNEA, AB-MECA, IB-MECA or Cl-IB-MECA. The A3RAg is preferably administered orally with a pharmaceutically acceptable carrier.

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Rishon Lezion, Israel

Lea Madi