China Petroleum Chemical Corporation

Shanghai Research Institute of Petrochemical Technology, Sinopec

Microsoft Technology Licensing, LLC

Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.

Sunshine Guojian Pharmaceutical (Shanghai) Co., Lt

Le Zhao

Lianghua Wu

Jun Xu

Siqing Zhong

Zhenping Zhu

Haomin Huang

Jianhe Chen

Jie Zhao

Fei Xu

Yawei Wang

Ken Chen

Qingrou Li

Jinlin Guo

Chenghai Zhang

Xiaoyan Zhao

Xuesai Zhang

Honghai Gao

Wei Dang

Lingqiao Zhu

Disclosed is a fluidized bed reactor and a heat removal water pipe and application thereof in acrylonitrile production. The fluidized bed reactor comprises at least a reaction cooling section and a vertical inner component provided in the reaction cooling section. Where, at a cross section transverse and perpendicular to a central axis of the fluidized bed reactor, an area of the cross section of the reaction cooling section is designated as S1 (expressed in a unit of m) and an outer contour circumference of the cross section of the vertical inner component is designated as L1 (expressed in a unit of m), L1/S1=2.0-4.3 m. The fluidized bed reactor can promote the breaking of bubbles as early as possible and effectively limit the growth of the bubbles.

Fluidized bed reactor, heat removal water pipe and application thereof in acrylonitrile production

Provided is an antibody binding to human HER2 or an antigen-binding fragment thereof capable of specifically binding to human HER2. Compared with Perjeta, the combination of the antibody or an antigen-binding fragment thereof and Herceptin has improved biological activity in inhibiting the proliferation of tumor cells overexpressing HER2. The antibody or an antigen-binding fragment thereof has an antigen-binding epitope different from known antibodies binding to human HER2, can be used to prepare a drug for treating a disease related to HER2 overexpression, such as cancer, and has good prospects for clinical application.

Antibody binding to human HER2 and preparation method and use thereof

A gas replacement process and a gas replacement apparatus are employed, in the nitro compound hydrogenation reaction process. The gas replacement process at least includes a first step of subjecting a stream to be replaced to the gas replacement in presence of a first replacement gas, and then a second step of subjecting to the gas replacement in presence of the second replacement gas. Assuming the superficial velocity of the first replacement gas is V1, and the superficial velocity of the second replacement gas is V2, then V2/V1≥1.5.

Gas replacement process, gas replacement apparatus, and nitro compound hydrogenation reaction process

A fluidized apparatus contains a double-trapezoid structural member. These fluidized apparatuses are used in the nitro compound hydrogenation reaction process. The fluidized apparatus includes a shell, a gas distributor, and an inner chamber defined by an inner wall of said shell and an upper surface of said gas distributor, in the middle region of said inner chamber is disposed a perforated plate, the perforated plate comprise an outer edge region and a center region, assuming the opening rate of the outer edge region is A1 (the unit is %), assuming the opening rate of the center region is A2 (the unit is %), then A1/A2=0-0.95.

Double-trapezoid structural member, fluidized apparatus and nitro compound hydrogenation reaction process

A fluid distributor includes one or more fluid transport main pipe. The fluid transport main pipe is configured to assume a closed shape when its centerlines and/or centerline extensions are joined end-to-end. Each of the fluid transport main pipe has at least one fluid inlet and is connected with a plurality of fluid transport branch pipes. Each of the fluid transport branch pipes has a plurality of open pores disposed along the length of the fluid transport branch pipe and a connection portion. The connection portion is configured to connect the fluid transport branch pipe to the housing after the fluid transport branch pipe passes through the housing of the vessel into the inner cavity.

Fluid distributor, reaction device and application thereof

One example provides a computing system configured to provide scalable, real-time duplex communications across a data network, the computing system comprising one or more processors, and storage comprising instructions executable by the one or more processors to instantiate one or more real-time duplex communication service instances. Each real-time duplex communication service instance comprises a real-time duplex communication framework comprising a client hub configured to receive connections for a plurality of clients and a server hub configured to receive connections for a plurality of servers, and each real-time duplex communication service instance is configured to publish messages regarding a state of the real-time duplex communication framework to a channel accessed by other real-time duplex communication service instances.

Scalable real-time duplex communications service

An anti-human PD-1 monoclonal antibody, and a preparation method therefor and an application thereof. The anti-human PD-1 monoclonal antibody has good bioactivity, can effectively bind with an extracellular region of a human PD-1 protein receptor, and can effectively seal PD-1 protein at protein level and cellular level and block the binding of the PD-1 protein with a ligand PD-L1, thereby effectively enhancing immunity. The monoclonal antibody can be applied independently or jointly with other antitumor drugs to tumor immunotherapy and the diagnosis and screening of patients with PD-L1 positive tumors; and the monoclonal antibody has a promising prospect in the preparation of drugs for treating tumors, resisting autoimmune diseases and the like.

Anti-PD-1 monoclonal antibody, and preparation method therefor and application thereof

The present invention relates to a preheating process and a start-up process for the ammoxidation reaction. The preheating process or the start-up process at least includes the step of heating the catalyst bed in the ammoxidation reactor while controlling the reactor operation linear speed to 0.03-0.15 m/s. The start-up process of the present invention has the advantages such as the significantly reduced launch time compared with the prior art and the operation safety.

Preheating process and start-up process for the ammoxidation reaction

A feed gas feeding system for a propylene ammoxidation reactor comprises a feed gas mixing system and a feed distributor, wherein a propylene and ammonia mixed gas is mixed by the feed gas mixing system and then uniformly distributed in the propylene ammoxidation reactor by the feed distributor. The initial temperature Twhen the propylene and ammonia mixed gas enters the feed distributor is 10-220&#xb0; C. The feed gas feeding system can prevent the temperature of the gas mixture at any position in the feed distributor from reaching a temperature at which ammonia decomposes into active nitrogen atoms, thereby reducing a risk of brittle nitriding fractures of the feed distributor.

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Shanghai, China

Le Zhao