10x Genomics, Inc.

Layla Katiraee

Marlon Stoeckius

Christina Galonska

Augusto Manuel Tentori

Hanyoup Kim

David Sukovich

Caroline Julie Gallant

James Michael Chell

Jonathan Alles

Michael Schnall-Levin

Lauren Gutgesell

Janine Hensel

Seayar Mohabbat

Felice Alessio Bava

Cedric Uytingco

David Maurice Cox

Kristen Pham

Yifeng Yin

Jennifer Chew

Jerald Sapida

Spontaneous Rose McKnight Russell

Spontaneous Rose Mcknight Russell

Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.

Methods, compositions, and systems for spatial analysis of analytes in a biological sample

Provided herein are methods for capturing an analyte from a first region of interest of a biological sample on a substrate, where the biological sample comprises the first region of interest and a second region, and where the method includes contacting the second region with a sealant in order to create a hydrophobic seal thereby preventing an interaction between an analyte from the second region with a capture domain of a capture probe.

Methods for increasing resolution of spatial analysis

A substrate holder includes a base configured to receive a substrate; a cover configured to mateably engage with the base, the cover defining an opening formed by inner sidewalls; and a removable insert defining a surface, the removable insert being configured to be received within the opening of the cover. The removable insert includes a gasket; a projection coupled to the gasket; and at least two insert tabs extending from opposite sides of the removable insert, each insert tab being configured to engage with at least one of the inner sidewalls forming the opening of the cover.

Modular assay support devices

Methods, compositions, and systems for capturing probes and/or barcodes

Provided herein are methods of enhancing spatial resolution of an analyte using sandwich maker system. The methods and systems used herein include a first substrate that includes a plurality of probes that include a capture domain and a spatial domain and a second substrate that includes a plurality of probes comprising a capture domain and a spatial domain.

Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis

Provided herein are methods of identifying a methylation status of an analyte in a biological sample. Also provided herein are methods that combine identifying the methylation status with spatial technology to identify the location of a methylation status in a biological sample.

Spatial analysis of epigenetic modifications

Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

Methods for spatial analysis using RNA-templated ligation

Provided herein are methods for simultaneous spatio-temporal measurement of gene expression and cellular activity.

Simultaneous spatio-temporal measurement of gene expression and cellular activity

Spatial analysis of DNA methylation

Growing community of inventors

Pleasanton, CA, United States of America

Layla Katiraee