Bristol-myers Squibb Compnay

Laxman Pasunoori

Alaric J Dyckman

Sreekantha Ratna Kumar

Christopher P Mussari

Dharmpal S Dodd

Subramanya Hegde

Trevor C Sherwood

John E Macor

Shoshana L Posy

Tasir Shamsul Haque

Ramesh Kumar Sistla

Brian K Whiteley

Louis John Lombardo

Anupama Kandhi Ramachandra Reddy

Rushith Kumar Anumula

John L Gilmore

Srinivasan Kunchithapatham Duraisamy

Pitani Veera Venkata Srinivas

Michael A Poss

David R Tortolani

William R Ewing

Philip Michael Sher

Chongqing Sun

Yeheng Zhu

Yanting Huang

Louis J Lombardo

Maheswaran Sivasamban Karatholuvhu

Scott A Bolton

Sunil Kumar Mandal

Durga Buchi Raju Barre

Vikram Bhogadi

Tasir Shamsul Hague

Anupame Kandhi Ramachandra Reddy

Anupama Ramachandra

Subramaya Hegde

Srinivasan Kunchithaptham Duraisamy

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein X, Y, A, G, R, and Rare defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted bicyclic heteroaryl compounds

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted benzimidazolone compounds

Disclosed are compounds of Formula (I) or a salt thereof, wherein R, R, R, R, R, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

[1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted indole compounds useful as TLR inhibitors

4-azaindole compounds

Disclosed are compounds of Formula (I) or salts thereof, wherein Ring Het, R, R, R, R, R, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted indole compounds

N-oxides, or salts thereof, wherein G, L, R, R, R, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Amide substituted indole compounds useful as TLR inhibitors

Disclosed are compounds of Formula (I) or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Aryl and heteroaryl substituted indole compounds

Disclosed are compounds of Formula (I) or a salt thereof, wherein R, R, R, R, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors

[1,2,4]triazolo[1,5-A]pyridinyl substituted indole compounds

4-Azaindole compounds

Growing community of inventors

Warangal, India

Laxman Pasunoori