Aligos Therapeutics, Inc.

Laxman Eltepu

Leonid Beigelman

Markus Hossbach

Vivek Kumar Rajwanshi

Rajendra K Pandey

N Tilani S De Costa

Jin Hong

Saul Martinez Montero

Described are short interfering nucleic acid (siNA) molecules comprising modified nucleotides, compositions, and methods and uses thereof.

Modified short interfering nucleic acid (siNA) molecules and uses thereof

Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2'-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2'-O-methyl nucleotides and 2&#x2032;-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5&#x2032;-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

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San Ramon, CA, United States of America

Laxman Eltepu