Depuy Synthes Products, Inc.

Amgen Inc.

Unl Holdings LLC

Unitract Syringe Pty Ltd

Other

Synthes USA, LLC

Synthes Gmbh

Lawton Laurence

Ian B Hanson

Paul F Bente, Iv

Joshua McManus

Mark A Destefano

Wamis Singhatat

David T Banks

John Christian Love

Vincent E Mandes

Heather Cannon

Dominique D Messerli

Antonio Ubach

Tom Overes

Kevin Lee Bokelman

Sean Hamilton Kerr

Daniel Shawn Codd

Thomas Kueenzi

David Edgar Evans

Ryan T Walsh

Rajan Ramaswamy

William Miller

Kurt Schmura

Matthew J Clemente

Thomas Pepe

Scott Beaver

Jared Schoenly

Daniel Vennard

Brandon L Randall

Jamie Manos

Ali Cem Recber

Thomas Donner

Ian P Dardani

Danielle Feldman

Robert Frigg

Sean Saidha

Andreas Appenzeller

Thomas R Keyer

Michael White

Edward J McShane, Iii

Joseph Capozzoli

Silas Zurschmiede

Eric McDivitt

Kun-Chi Wu

Justin Coppes

Khawar Mohammad Siddique

Brian Regis Perri

Iv Bente Paul F

Sheldon B Moberg

Scott Robert Gibson

Margaux Frances Boyaval

Sean M O'connor

Basel Hasan Taha

Kevin L Bokelman

Daniel S Codd

Robert Scott Russo

Shaun Robert Devitt

James Talbot

Alexis Marie Adolphe Dechelette

Joshua Mcmanus

Ken Underhill

Robert Trzybinski

Paul Bente

Rudolf Bertagnoli

John C Love

Adam I Lehman

Scott P Larsen

Ray Adams

Joel Helfer

Vincent Mata

Alexis Marie Dechelette

Robert G Jeter

Ali Recber

Randall Brandon

Scott R Gibson

Iv Paul F Bente

Paul F Iv Bente

Khawar Mohammed Siddique

David Evans

Vinny Mata

Ryan Walsh

Edward J Mcshane Iii

The present invention provides devices and methods for establishing aseptic connections between two or more components or subassemblies. The devices may be used in medical devices such as drug delivery pumps (). In some embodiments, a connection is made between a drug container () and a fluid pathway connection assembly (). The fluid pathway connection assembly may include a connection hub (), a piercing member (), and a piercing member retainer (). The assembly may further include a first film () covering a cavity (A,A,A), thereby maintaining the aseptic condition of the cavity. The drug container may hold a fluid drug and include a pierceable seal (). A second film () may cover a recess () formed by the seal and thereby maintain the aseptic condition of the interior of the chamber. The piercing member may be caused to pierce the first and second film and the pierceable seal to open a fluid pathway for delivery of the fluid drug through the fluid pathway connection assembly.

Device and method for making aseptic connections

A drive mechanism () for use with a drug container () in a drug pump, the drug container () having a barrel () and a plunger seal (), including a tether, an electrical actuator () and a gear interface. Rotation of the gear interface is controlled by the actuator (). A gear assembly rotationally engages with the gear interface. The gear assembly includes a main gear and a regulating mechanism. Release of the tether is metered by the gear assembly through the regulating mechanism. A piston () is connected to the tether and is disposed in the barrel () and configured to translate axially within the container. A biasing member is disposed at least partially within the barrel () and is retained in an energized state between the piston () and drive housing, wherein the release of the tether controls the free expansion of the biasing member from its energized state and the axial translation of the piston ().

Drug delivery device and method

Arcuate fixation members with varying configurations and/or features are provided, along with additional components for use therewith in provided fixation systems and intervertebral implant systems. The arcuate fixation members may be of varying lengths, cross sectional geometries, and/or cross sectional areas, and may be configured with various features such as heads configured to accept other fixation system components, tabs to allow arcuate fixation member-in-arcuate fixation member or fixation anchor-in-arcuate fixation member configurations. Applications of fixation systems and intervertebral implants systems utilizing arcuate fixation members are particularly suitable when a linear line-of-approach for delivering fixation members is undesirable.

Arcuate fixation member

An insertion mechanism for a drug pump includes an insertion mechanism housing; a sleeve; a rotational biasing member initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the sleeve. The needle is inserted into a target tissue by the rotational biasing member and interaction between the hub and housing. Retraction of the needle is caused by decompressing or de-energizing of the retraction biasing member. A drug delivery pump includes an activation mechanism, a drive mechanism, a sterile access connection, and the insertion mechanism. Assembly and operation methods are provided.

Rotationally biased insertion mechanism for a drug delivery pump

Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.

Drug delivery device, method of manufacture, and method of use

Power and control systems for a drug delivery device allow for the activation, control of, and communication with the drug delivery device. The power and control system allows for a delay between device activation, and optionally needle insertion, and commencing drug delivery. The delay may be for a predetermined time. In addition, the power and control system may communicate with one or more external sensors and devices. The inputs from the sensors and devices may automatically, or on demand, adjust the delivery parameters of the device. The power and control systems may control a drive system that delivers a fluid at a variable rate or profile, allowing for the delivery to be tailored to maximize the effectiveness of the treatment.

Systems and methods for controlled drug delivery pumps

An intervertebral implant for insertion into an intervertebral disc space between adjacent vertebral bodies or between two bone portions. The implant includes a spacer portion, a plate portion operatively coupled to the spacer portion and one or more blades for securing the implant to the adjacent vertebral bodies. The blades preferably include superior and inferior cylindrical pins for engaging the adjacent vertebral bodies. The implant may be configured to be inserted via a direct lateral trans-psoas approach. Alternatively, the implant may be configured for insertion via an anterior approach.

Intervertebral implant with blades for connecting to adjacent vertebral bodies

The present disclosure relates to a spinal implant. The spinal implant may be used for lateral insertion into an intervertebral disc space. For example, the spinal implant may include a spacer body to which a plate is fixed. The intervertebral spacer body may include a pair of opposite sides having a pyramid-shaped teeth to fuse to bone. The plate defines at least one upper and lower borehole that each receives a screw. Each screw attaches the plate to a vertebral body between which the intervertebral spacer body is inserted. The boreholes may include locking threads that are adapted to lock the screws into place by engaging complementary locking threads of head of the screw.

Lateral insertion spinal implant

Embodiments described include devices and methods for forming a porous polymer material. Devices disclosed and formed using the methods described a spacer for spinal fusion, craniomaxillofacial (CMF) structures, and other structures for tissue implants.

Porous biocompatible polymer material and methods

Drive mechanisms for drug delivery pumps

Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device includes a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector defines a sterile fluid flowpath between the container and the insertion mechanism. A cannula initially disposed about the needle is included.

Growing community of inventors

West Chester, PA, United States of America

Lawton Laurence