Abbott Laboratories Corporation

Lawrence V Howard

Eric B Shain

Joan D Tyner

Jeffrey C Hunt

Tuan A Elstrom

Gregory Thomas Maine

Thomas E Rohr

Michael Jyh-Tsing Sheu

Susan Brojanac

Linda E Chovan

Jack S Remington

Alan S Armstrong

John E Herrmann

Stephen F Parmley

Fausto Araujo

Yashuhiro Suzuki

Shuli Li

MaryCaren Craine

Gregory T Maine

Shuili Li

The present invention relates to combinations or mixtures of antigens which may be used in the detection of IgM and/or IgG antibodies to,. Furthermore, the present invention also relates to methods of using these combinations of antigens, antibodies raised against these combinations of antigens or against the novel P29 antigen thereof, as well as kits and vaccines containing the antigens present in the combinations.

Antigen cocktails and uses thereof

Assay methods utilizing the response of a magnetically responsive reagent to the influence of a magnetic field to qualitatively or quantitatively measure binding between specific binding pair members. According to the invention, the presence of an analyte mediates whether or not the magnetically responsive reagent binds to a mobile solid phase reagent. The extent of binding will modulate the response of the magnetically responsive reagent or that of the mobile solid phase reagent, or both, to the influence of a magnetic field. Hence, by measuring the response to the magnetic field of the magnetically responsive reagent, or that of the mobile solid phase reagent, the presence or amount of analyte contained in a test sample can accurately be determined. The invention utilizes various devices to carry out the assay methods described.

Magnetically assisted binding assays utilizing a magnetically responsive reagent

The present invention relates to combinations or mixtures of antigens which may be used in the detection of IgM and/or IgG antibodies to,as well as to the P35 antigen which may be used to distinguish acute from chronic toxoplasmosis. Furthermore, the present invention also relates to methods of using these combinations of antigens, antibodies raised against these combinations of antigens or against the novel P29 antigen thereof, as well as kits and vaccines containing the antigens present in the combinations.

Method of using P35 antigen of toxoplasma gondii in distinguishing acute from chronic toxoplasmosis

Magnetically assisted binding assays utilizing a magnetically responsive

In an assay where a ligand or organism is detected by a detector binding protein ('DBP') capable of generating a signal in proportion to the amount of ligand or organism bound to the DBP, the presence of the ligand or organism is confirmed by the use, prior to or concurrently with the DBP, of a confirmatory binding protein ('CBP') which binds to a second site on the ligand or organism, and thereby prevents the DBP from binding to the first site. Thus, a reduction in signal of a predetermined amount indicates the true presence of the ligand or organism, while failure to obtain signal reduction of a predetermined amount indicates that the original signal was a false positive due to assay artifact or detection of related ligands or organisms. In a preferred embodiment, the CBP is a monoclonal antibody and the organism is derived from Chlamydia species.

Two-site confirmatory assay

The present disclosure relates to a solid phase immunoassay for the detection of Chlamydia trachomatis antigens in a clinical specimen, wherein the Chlamydia trachomatis antigens to be determined are coated or adsorbed on the solid phase.

Immunoassay for Chlamydia trachomatis antigens

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Libertyville, IL, United States of America

Lawrence V Howard