Other

Biolink Partners

Lawrence S Udell

Alex Garfield Bonner

Gaston De Los Reyes

Fu-Jya Daniel Tsai

Richard A Laursen

Stephen Duly

William A Creasey

David Wells Andrews

A functional, porous, interpenetrating polymer network (IPN) includes a first polymer network in the form of a porogenic support fabric (PSF) composed of linear polymers in the form of a pre-formed network comprising a fibrous composite and a second polymer network synthesized, gelated, and/or cross-linked in the presence of the first polymer network to form a system of polymers which have their respective chains held in place by means of permanent physical entanglements produced by the interweaving of the component polymer networks. The IPN is modified by dissolving and dispersing a portion of the PSF fibers, the dispersible fiber network (DFN) to form a pre-designed interconnected pore structure. The resultant porous, supported, second polymer network has convective flow, diffusive flow, and high capacity, and may include functional capture chemistries to provide an adsorptive media for chromatography and filtration of various compounds including biomolecules.

Porous interpenetrating polymer network

A new method, solid phase precipitation and extraction (SPPE), is disclosed and is particularly advantageous for purifying mixtures of synthetic peptides directly from a cleavage/deprotection mixture.

Solid phase precipitation and extraction

Methods for preparing organic compounds, such as oligonucleotides, on solid supports are described. Libraries of the compounds and methods of using the compounds are also disclosed.

Solid phase synthesis of organic compounds via phosphitylating reagents

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Brookline, MA, United States of America

Lawrence S Udell