The Uab Research Foundation

Emory University

Children's Healthcare of Atlanta, Inc.

In8bio, Inc.

Lawrence S Lamb

Harold Trent Spencer

Anindya Dasgupta

G Yancey Gillespie

H Trent Spencer

Antonio Di Stasi

Larisa Pereboeva

Shin Mineishi

Ayman Saad

William Ho

The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic immune cell line and uses thereof in conjunction with cytotoxic drugs

Drug resistant immunotherapy for treatment of a cancer

The present disclosure provides novel cell compositions engineered to express at least a chimeric antigen receptor and a survival factor. Methods of using such cell compositions are also described.

Genetically engineered drug resistant T cells and methods of using the same

The invention provides chimeric antigen receptor(s) (CAR(s)) that comprise a fusion protein of CTX or any functional variant thereof or a CTX-like peptide or any functional variant thereof as the extracellular antigen recognition moiety of the CAR. CAR(s) comprising CTX, a CTX-like peptide or functional variants of the foregoing are collectively referred to herein as 'CTX-CAR(s).' Such CTX-CAR(s) may further comprise additional moieties or domains in the extracellular domain, a transmembrane domain and at least one intracellular! signaling domain. Such CTX-CAR(s) may be expressed in a host cell, such as, but not limited to, an immune effector cell. The present invention also provides methods of treatment (such as, for example, methods for treating cancer) by providing to the patient in need thereof immune effector cells that are engineered to express a CTX-CAR described herein.

Chimeric chlorotoxin receptors

The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic immune cell line and uses thereof in conjunction with cytotoxic drugs.

Growing community of inventors

Birmingham, AL, United States of America

Lawrence S Lamb