University of Washington

Lawrence R MacDonald

Robert S Miyaoka

Thomas K Lewellen

William C J Hunter

Paul Eugene Kinahan

Kyle Morgan Champley

The present technology describes various embodiments of positron emission tomography (PET) systems for use with mammography machines and associated devices and methods. In several embodiments, a PET system includes a tissue platform and one or more PET detection panels removably coupled to the mammography machine. The panels are configured to generally surround the tissue platform and obtain an approximately 360 degree data sample of tissue. The system can further include an output device configured to output the data sample for image reconstruction. In some embodiments, the system is configured to provide high resolution images, quantitative image accuracy, dynamic imaging, and/or biopsy guidance.

Positron emission tomography systems for use with mammography machines and associated devices and methods

A radiation detector is disclosed that includes a scintillation crystal and a plurality of photodetectors positioned to detect low-energy scintillation photons generated within the scintillation crystal. The scintillation crystals are processed using subsurface laser engraving to generate point-like defects within the crystal to alter the path of the scintillation photons. In one embodiment, the defects define a plurality of boundaries within a monolithic crystal to delineate individual detector elements. In another embodiment, the defects define a depth-of-interaction boundary that varies longitudinally to vary the amount of light shared by neighboring portions of the crystal. In another embodiment the defects are evenly distributed to reduce the lateral spread of light from a scintillation event. Two or more of these different aspects may be combined in a single scintillation crystal. Additionally, or alternatively, similar SSLE defects may be produced in other light-guiding elements of the radiation detector.

Optical-interface patterning for radiation detector crystals

A method for estimating a line or response in a positron emission tomography scanner having depth of interaction estimation capability. The method utilizes information from both detector modules detecting a coincident event. A joint probability density function combining factors accounting for intermediate Compton scattering interactions and/or a final interaction that may be either a Compton scattering interaction or photoelectric absorption is calculated. In a preferred embodiment, a Bayesian estimation scheme is used to integrate the PDF for all permutations of the measured signal pairs, and the permutation with the largest joint probability is selected to construct the estimated line of response.

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Seattle, WA, United States of America

Lawrence R MacDonald