Merck + Co., Inc.

Lawrence R Koupal

Otto D Hensens

Jerrold M Liesch

Leeyuan Huang

Anne W Dombrowski

H Boyd Woodruff

Joseph Dunn, Jr

Roger M Freidinger

Deborah L Zink

Gerald F Bills

Russell B Lingham

Paul S Anderson

Yiu-kuen T Lam

Michael A Goetz

Douglas J Pettibone

John G Ondeyka

Cheryl D Schwartz

Robert P Borris

This invention relates to processes employing cultures which are useful for preparing compounds of structural formula (I). ##STR1##

Processes for preparing cholesterol lowering compounds

An alkyl indole of the formula: ##STR1## is a useful antimigraine agent.

Antimigraine alkyl indole

An antiviral agent produced by Hypoxylon fragiforme and having the structure: ##STR1## is described. The product has high activity as an HIV protease enzyme inhibitor and is useful in the treatment of diseases in which control of HIV protease activity is desirable.

Antiviral agent

This invention relates to cultures and processes employing these cultures which are useful for preparing compounds of structural formula (I). ##STR1##

Culture of Asperigillus versicolor and mutants thereof

Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis, ATTCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.

Oxytocin and vasopressin antagonists

A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and congestive heart failure.

Renin-inhibitory pepstatin phenyl derivatives

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Colonia, NJ, United States of America

Lawrence R Koupal