First Medical, Inc.

Lawrence M Ensler

Michael P Allen

Stoughton L Ellsworth

Robert F Zuk

Kumar Subramanian

Arjuna Ragunath Karunaratne

Eric K Gustafson

An analytical system comprises a frame and movable carriage. An analytical rotor is mounted on the carriage and can be translated among a sample dispensing station, a fluid dispensing station, and a label detection zone. In order to perform assays, the analyzer system requires only the introduction of the analytical rotor, sample, and a volume of diluent solution. Sample within the analyzer is contained at all times within either a sample receptacle or the rotor. The method allows for the sequential addition of sample and diluent in order to perform multiple assay steps and is particularly suitable for performing heterogeneous immunoassays. The use of fluorescent label in the system allows multiple analyte detection reactions to be performed from a single sample applied to a single rotor.

System and methods for performing rotor assays

A system for separating plasma from whole blood comprises a blood separation device and a blood separation driver. The blood separation device includes a flexible tube having a needle and shield at one end and a filter member at the other end. The needle may be used to access blood in a conventional blood collection device. The separation driver applies a peristaltic force to the flexible tube of the blood separation device, thus drawing blood from the collection device through the tube and to the filter member. The driver also includes a frame having a collar and clamp mechanism for supporting the inlet end of the flexible tube, thus allowing use of the blood driver without directly exposing it to the blood. Plasma may be collected from the filter element. The present invention also provides blood dispensing systems and methods for dispensing whole and pre-filtered blood. Such blood dispensing systems comprise a blood dispensing device and a blood dispensing driver.

Peristaltic system and method for plasma separation and blood

A system for separating plasma from whole blood comprises a blood separation device and a blood separation driver. The blood separation device includes a flexible tube having a needle and shield at one end and a filter member at the other end. The needle may be used to access blood in a conventional blood collection device. The separation driver applies a peristaltic force to the flexible tube of the blood separation device, thus drawing blood from the collection device through the tube and to the filter member. Plasma may be collected from the filter element.

Blood separator system

The system for transferring plasma to a test substrate comprises an applicator and the test substrate. The applicator includes a blood reservoir and a filter element which separates cellular components from the blood as plasma is passed to the test substrate. The test substrate includes an absorptive element which receives the plasma from the applicator. In one embodiment, measured amounts of plasma are transferred when the absorptive element becomes saturated, thus stopping the flow of plasma. In another embodiment, excess blood and cellular components are removed from the measured plasma by disengaging the applicator from the test substrate. In another embodiment, plasma transferred to the absorptive element is eluted from the absorptive element by subsequent application of an elution medium.

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Los Altos, CA, United States of America

Lawrence M Ensler