University of Texas System

Other

Lawrence Lum

Chuo Chen

Wei Tang

Michael G Roth

Ozlem Kulak

Baozhi Chen

Michael E Dodge

Nageswari Yarravarapu

Lin You

Chengwei Zhang

Xiaolei Wang

Lishu Zhang

Xuewu Zhang

Xiaofeng Wu

Mike Roth

Michael Dodge

The present disclosure provides compounds that may be useful for inhibiting Wnt pathway comprising compounds of the formula: (Ia) or (Ib) wherein the variables are as defined herein. In some aspects, the compounds may be used to inhibit the Wnt pathway and used to treat cancer, myocardial infarction, osteopetrosis, or used in the maturation of a precursor cell to a mature cell. Also provided herein in are pharmaceutical compositions of the compounds described herein. 

Disubstituted and trisubstituted 1,2,3-triazoles as Wnt inhibitors

The present disclosure provides compounds that may be useful for inhibiting the Tankyrase enzyme. In some aspects, these compounds are useful in the treatment of a disease or disorder related to the misregulation of Tankyrase enzyme such as cancer, degenerative diseases, or fibrotic diseases. Also provided herein are compounds may also be used to prevent the elongation of the telomere in a cell.

Indolinyl-sulfonamide inhibitors of tankyrase and methods of use thereof

The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.

Highly potent inhibitors of porcupine

WNT protein signalling inhibitors

Inhibitors of luciferase enzymes are disclosed and find use in multiplexed assays using multiple luciferases and multiple inhibitors, in both in vitro and in vivo embodiments.

Multiplexed luciferase reporter assay systems

Wnt protein signalling inhibitors

Growing community of inventors

Dallas, TX, United States of America

Lawrence Lum