New Horizons Diagnostics Corporation

Other

The Rockefeller University

Prognosys LLC

New Horizons Diagnostic, Corp

New Horizon Diagnostics Corporation

Lawrence J Loomis

Vincent A Fischetti

C David Miller

Marc Harry Cohen

David Trudil

Kenneth A Gabriel

A diagnostic test device comprising at least one membrane disposed in any of one, two, and three dimensions; at least one test sample fluid input port that receives and transfers at least one test sample fluid and onto the at least one membrane; at least one contiguous fluid flow manifold within the at least one membrane to multiplex or distribute the at least one test sample fluid; at least one contiguous fluid flow channel that operatively connects the at least one membrane to the at least one contiguous fluid flow manifold; at least one analyte assay test zone disposed within the at least one contiguous fluid flow channel; and at least one chemical capturing reagent disposed within the at least one analyte assay test zone, wherein multiple analyte assay test results are simultaneously obtained and in parallel in the diagnostic test device.

Multiplexed lateral flow assay arrays

A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.

Time release patch containing phage associated lytic enzymes for treating bacterial infections of the skin

A lozenge for the treatment ofGroup A infections of the mouth, throat, and nasal passage is disclosed which comprises a lytic enzyme composition specific forGroup A and a lozenge carrier for delivering the lytic enzyme.

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The present invention discloses a composition for dermatological infections by the use of a lytic enzyme in a carrier suitable for topical application to dermal tissues. The method for the treatment of dermatological infections comprises administering a composition comprising effective amount of a therapeutic agent, with the therapeutic agent comprising a lytic enzyme produced by infecting a bacteria with phage specific for that bacteria.

Bandage composition containing phage associated lytic enzymes useful for treating dermatological infections

The present invention relates to an oral delivery system containing a bacteriophage associated lysin enzyme for the treatment of [and]sinus/nasal infections.

Use of bacterial phage associated lysing enzymes for treating upper respiratory illnesses

The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for that bacteria and an appropriate carrier for delivering the lytic enzyme into a patient. The injection can be done intramuscularly, subcutaneously, or intravenously.

Syrup composition containing phage associated lytic enzymes

A nasal spray for treating ainfection is disclosed. The spray comprises an effective amount of a lysin enzyme genetically coded for by a Cbacteriophage capable of infecting a group Cbacteria, and a nasal spray carrier for delivering said lysin enzyme to a mouth, throat, or nasal passage.

Nasal spray for treating streptococcal infections

Method for the treatment of bacterial vaginal infections

A method for treating ainfection is disclosed using a nasal spray. The spray comprises an effective amount of a lysin enzyme genetically coded for by a C1 bacteriophage capable of infecting a group Cbacteria, and a nasal spray carrier for delivering said lysin enzyme to a mouth, throat, or nasal passage.

Therapeutic treatment of upper respiratory infections using a nasal spray

A tampon for treatment ofGroup B infections of the vagina is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering the lytic enzyme.

Tampon for the treatment of Streptococcus Group B infections of the vagina

A method for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The composition may be in the form of an isotonic solution.

Method for the treatment of bacterial eye infections

A method for the prophylactic and therapeutic treatment of bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of a native or modified version of a lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria. The lytic enzyme is selected from a group consisting of shuffled lytic enzymes, chimericlytic enzymes, wherein the lytic enzyme is in an environment having a pH which allows for activity of said lytic enzyme; and a carrier for delivering said lytic enzyme. Additionally, a holin enzyme for puncturing the membrane may be included in the composition. This method, and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, and burns, vaginal infections, eye infections, intestinal disorders and dental problems.

Method of treating upper resiratory illnesses

A composition for treatment of bacterial infections of burns and wounds of the skin, comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria, and a carrier for delivering said at least one lytic enzyme to the skin. The carrier may be, but is not limited to, a liquid solution applied to a bandage.

Bandage composition containing a phage associated lytic enzyme

A lozenge for the treatment of infections of the mouth throat and nasal passage is disclosed which comprises a lytic enzyme composition specific for , and a lozenge carrier for delivering said lytic enzyme.

Throat lozenges for the treatment of Hemosphilus influenza

A chewing gum composition produced by mixing an effective amount of lysin enzyme produced by group C streptococcal bacteria infected with a C1 bacteriophage and a carrier for delivering said lysin enzyme to a mouth, throat, or nasal passage.

Growing community of inventors

Columbia, MD, United States of America

Lawrence J Loomis