The Brigham and Women's Hospital, Inc.

Lawrence H Cohn

Victor J Dzau

Michael J Mann

Umer Sayeed-Shah

A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, such as coronary artery disease, is described. The method involves (i) creating injury in a tissue (e.g., muscle, such as cardiac muscle) by, for example, use of a laser, an ultrasonic device, or a Thermal probe, and (ii) injecting into the tissue a revascularization-promoting molecule or a nucleic acid molecule encoding a revascularization-promoting molecules Also described is an apparatus that can be used to practice this method.

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Chestnut Hill, MA, United States of America

Lawrence H Cohn