Other

Apnimed, Inc. (delaware)

Lawrence G Miller

Barry Wohl

Walter J Lunsmann

In general, the invention relates to pharmaceutical compositions comprising (R)-oxybutynin and a norepinephrine reuptake inhibitor (NRI) and methods of treating Sleep Apnea comprising administering (R)-oxybutynin and a norepinephrine reuptake inhibitor (NRI). In some embodiments, the NRI is atomoxetine.

Methods for treating sleep apnea with combinations of atomoxetine and (R)-oxybutynin

A container opening device is designed for use with waxed paper board cartons of the type utilized for packaging milk, orange juice and other beverages. These cartons have an initially closed dispensing opening formed by a pair of overfolded flaps intersecting at a central apex. The present invention includes a manual grasping element secured by a cord to the central apex to facilitate opening of the carton. The manual grasping member may comprise a ring for finger insertion or a small spherical ball. The cord is secured to a reinforcement strip which may be adhesively secured to an exterior surface of the cart or sandwiched between the paper board layers forming the carton.

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Cambridge, MA, United States of America

Lawrence G Miller