Circe Biomedical, Inc.

Nomadics, Inc.

Flir Detection, Inc.

Akita Innovations LLC

Normadics, Inc.

Lawrence F Hancock

Robert Deans

Alan Jay Kishbaugh

Timothy Manning Swager

Marc E Parham

Aimee Rose

Kevin M Bardon

Richard A Minns

Matthew Szabo

Wei Chen

William A McDaniel

Stephen M Fagan

Peter G Loges

Kateri E Paul

Claudy J-p Mullon

Marc Ellous Parham

Articles and methods related to the manufacture of polymers containing labile crosslinking moieties are generally described.

Articles and methods related to labile crosslinking moieties

Embodiments described herein related to devices and methods for the collection and/or determination of analytes, such as illicit substances including military explosives, explosives, and precursors thereof. In some cases, the device may be a disposable device that incorporates highly efficient sample collection in combination with microfluidic-based chemical analysis resulting in the rapid detection and identification of unknown materials. In some cases, multiple colorimetric detection chemistries may be employed, and the resulting 'barcode' of color changes can be used to positively identify the presence and/or identity of the analyte.

Device and methods for detection of analytes including use of a colorimetric barcode

The present invention provides a series of systems, devices, and methods relating to the determination of explosives, such as peroxides or peroxide precursors, and other species. Embodiments of the invention may allow a sample suspected of containing an explosive (e.g., a peroxide) or other species to interact with a reactant, wherein the sample may react and cause light emission from the reactant. Advantages of the present invention may include the simplification of devices for determination of peroxide-based explosives, wherein the devices are portable and, in some cases, disposable. Other advantages may include relative ease of fabrication and operation.

Detection of explosives and other species

This invention involves a series of articles, dispersions, compositions, methods, and kits. Several aspects of the invention involve dispersed particles made from polymers having a delocalized &#x3c0;-orbital backbone structure, as well as methods for making and using such particles. The delocalized &#x3c0;-orbital backbone allows the polymer to have a high degree of luminosity, useful in many embodiments of the invention. The polymers of this invention can also have bulky substituents to prevent intermolecular &#x3c0;-&#x3c0; interactions that can decrease luminosity. The polymer may also have charged side chains immobilized relative to the backbone, which can allow the polymer to be made into stably suspended micro- or nanoparticles dispersed in solution, sometimes with very narrow size distributions. In some embodiments, depending on the conditions used to synthesize and prepare the particles, the particles each consist of a single polymer molecule. Side groups, including biological, biochemical, or chemical molecules, can be attached to the polymer to provide additional functions, such as altering the luminosity of the polymer, or allowing the polymer to bind to certain molecules, such as in a chemical sensor or in a biological assay. As the binding of a molecule to a side group on the polymer can affect the structure of the polymer or alter the luminosity of the particle, the particles of the invention may be used, in certain embodiments, to detect the presence of single molecules.

Luminescent polymer particles

The present invention relates to a block copolymer containing 1-50 first polymer segments and 1-50 second polymer segments. Each first polymer segment has an average mole fraction of monomers possessing a branch point of 0.0001 to 1, whereas each second polymer segment has an average mole fraction of monomers possessing a branch point of 0 to 0.5. The average molecular weights range from 5-2,000 kDa for the first polymer segments, which constitute 5-95% by weight of the block copolymer. The average molecular weights also range from 5-2,000 kDa for the second polymer segments, which constitute 5-95% by weight of the block copolymer. The ratio of the average mole fraction of monomers possessing a branch point of the second polymer segments to that of the first polymer segments is 0 to 0.5. An example of such a copolymer has ethylene oxide or ethylene oxide/propylene oxide as the first polymer segment and polysulfone as the second polymer segment. This block copolymer can further be blended with a bulk polymer.

Highly branched block copolymers

A poly(ethyleneoxy) block copolymer including a hydrophobic block segment useful in making a porous polymer article with improved surface hydrophilicity. Also disclosed is a method of making such a polymer article.

Block copolymers

An amphiphilic block copolymer including a hydrophilic internal segment and polymeric articles made therefrom.

Thermoplastic block copolymers

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North Andover, MA, United States of America

Lawrence F Hancock