Cedars-sinai Medical Center

Alfred E. Mann Foundation for Scientific Research

Medallion Therapeutics, Inc.

Cedars-sinai Medical

Lawrence Eric Ong

Robert James Siegel

Scott Robert Gibson

Brian Michael Shelton

Sam William Bowman

Niclas Henning Zieger

John Paul D'Brot

Werner Hafelfinger

Richard E Purvis

Henning Zieger

A fixation device for securing together leaflets of a heart valve is provided. The fixation device may comprise two plates that are disposed on either side of the tricuspid valve. The plates may be secured to one another by a locking clip, thereby securing the valve leaflets between the plates.

Device for securing heart valve leaflets

Catheter apparatuses and methods are provided for repairing heart valves, particularly mitral valves. The method includes providing a catheter having an elongate, flexible body, with a proximal end and a distal end. The distal end can be transluminally advanced from the left atrium through the mitral valve. A distal anchor zone or portion coupled with the proximal end can extend and along the left ventricular outflow tract into the ascending aorta. A valve repair device is deployed to permanently connect leaflets at a mid-section of a mitral valve while permitting medial and lateral portions of the natural leaflets to open and close. The catheter apparatuses may be positionable using a steering device. The valve repair device detachably connects the distal and proximal ends of the catheter. The valve repair device can be detached using low profile devices actuatable from the proximal or distal ends, e.g., at a venous or arterial access site.

Method and apparatus for percutaneous delivery and deployment of a cardiac valve prosthesis

Catheter apparatuses and methods are provided for repairing heart valves, particularly mitral valves. The method includes providing a catheter having an elongate, flexible body, with a proximal end and a distal end. The distal end can be transluminally advanced from the left atrium through the mitral valve and along the left ventricular outflow tract into the ascending aorta. A valve repair device is deployed to permanently connect leaflets at a mid-section of a mitral valve while permitting medial and lateral portions of the natural leaflets to open and close. The valve repair device detachably connects the distal and proximal ends of the catheter.

Method and apparatus for percutaneous delivery and deployment of a cardiovascular prosthesis

A heart valve prosthesis is provided that includes a first member and a second member. The first member comprises a first central portion to be disposed adjacent to a line of coaptation on a first side of two adjacent heart leaflets and peripheral portions to be placed into direct contact with the two adjacent heart leaflets. The second member is separate from or can be separable from the first member, for example during delivery. The second member has a central portion and peripheral portions configured to be placed into direct contact with a second side of the two adjacent heart leaflets.

Infusion devices with blockage detection capability and methods of monitoring infusion devices.

Ambulatory infusion devices and methods

Infusion devices with blockage detection capability and methods of monitoring infusion devices. High resolution pressure sensing and/or the sensing of a reflected pressure event may be used to detect a blockage.

Growing community of inventors

Beverly Hills, CA, United States of America

Lawrence Eric Ong