Vestar, Inc.

Gilead Sciences, Inc.

City of Hope National Medical Center

Vestar Research, Inc.

Lawrence E Williams

George W Tin

Richard T Proffitt

Cary A Presant

Raymond L Teplitz

Ronald C Gamble

Micellular particles such as small unilamellar vesicles of less than 2000 A&deg; loaded with,In are administered to BALB/c mice in which EMT,tumors had been induced. Whole body scintographs of the mice to which either neutral or positively or negatively charged vesicles had been administered show a substantial quantity of the vesicle entrapped,In localized in the tumor. Blocking of macrophages in the liver and spleen by first administering unlabeled, aminomannose substituted vesicles before administration of the labeled vesicles increases uptake of the,In labeled vesicles in the tumor.

Method of targeting a specific location in a body using phospholipid and cholesterol liposomes which encapsulate an agent

A method is provided for delivering micellular particles containing chemotherapeutic agents and a marker to tumors within a body for the diagnosis and treatment of such tumors. The micellular particles are small, less than 2000 .ANG. and incorporate pure, neutral phospholipid molecules in their external surface. Enhanced delivery of the micellular particles containing marker and chemotherapeutic agents may be achieved by introducing an initial group of positively charged micellular particles to block the reticuloendothelial cells present in the body.

Method of delivering micellular particles encapsulating chemotherapeutic

Micellular particles such as small unilamellar vesicles of less than 2000 .ANG. loaded with .sup.111 In are administered to BALB/c mice in which EMT6 tumors had been induced. Whole body scintographs of the mice to which either neutral or positively or negatively charged vesicles had been administered show a substantial quantity of the vesicle entrapped .sup.111 In localized in the tumor. Blocking of macrophages in the liver and spleen by first administering unlabeled, aminomannose substituted vesicles before administration of the labeled vesicles increases uptake of the .sup.111 In labeled vesicles in the tumor.

Method of targeting a specific location in a body

Described herein is a process for labeling leukocytes and other phagocytic cells with labeled micellular particles involving incubating the cells with the micellular particles. Also described is a process for detecting the locus of an infection by administering to a subject leukocytes radiolabeled by incubation with labeled micellular particles followed by scanning the subject to detect the locus of radiation emitted by the particles.

Growing community of inventors

San Dimas, CA, United States of America

Lawrence E Williams