Trigeminal Solutions, Inc.

New York University

Monitrix, Inc.

Lawrence C Newman

Steven Elliot Stupp

Gert Lanckriet

Chris Carpenter

James Cramer

Provided are methods and compositions for treatment of tinnitus. The method comprises administration of therapeutically effective amount of oxytocin, which may be present with a thickener, and may be delivered to the back of the nasal cavity in a suitable form. Compositions of oxytocin for intranasal delivery and sprayable unit compositions of oxytocin are also provided.

Oxytocin compositions for treatment of tinnitus

An apparatus, and related method, for identifying one or more association variables is described. The apparatus includes at least one processor, at least one memory, and at least one program module stored in the memory configured to be executed by the processor. The program module includes instructions for selecting a subset of temporal onsets in a set of temporal onsets, instructions for determining a statistical relationship between the subset and a pattern of occurrence of a variable, and instructions for identifying the variable as an association variable in accordance with the statistical relationship. The subset includes one or more first temporal onsets corresponding to one or more instances of an event, and the set of temporal onsets includes the subset of temporal onsets and one or more second temporal onsets corresponding to one or more instances of a reoccurrence event.

Apparatus for determining association variables

An apparatus, and related method, for determining one or more association variables is described. The apparatus includes at least one processor, at least one memory, and at least one program module. The program module is stored in the memory and is configurable to be executed by the processor. The program module includes instructions for determining a statistical relationship between one or more temporal onsets corresponding to one or more events and a pattern of occurrence of a compound variable. The compound variable corresponds at least to a pattern of occurrence of a first variable and a pattern of occurrence of a second variable. The determining includes contributions from presence and absence information in the pattern of occurrence of the compound variable.

An apparatus, and related method, for determining one or more association variables is described. The apparatus includes at least one processor, at least one memory, and at least one program module stored in the memory configured to be executed by the processor. The program module includes instructions for selecting a subset of temporal onsets in a set of temporal onsets, instructions for determining a statistical relationship between the subset of temporal onsets and a pattern of occurrence of a variable, and instructions for identifying the variable as a migraine variable in accordance with the statistical relationship. The subset of temporal onsets includes one or more onsets corresponding to one or more migraines experienced by at least one individual, and the set of temporal onsets includes the subset of temporal onsets and one or more temporal onsets corresponding to one or more additional headaches experienced by at least the one individual.

An apparatus, and related method, for collecting information, such as that associated with one or more variables, is described. The apparatus may include at least one processor, at least one memory, and at least one program module. The program module may be stored in the memory and may be configurable to be executed by the processor. The program module may include instructions for a set of pre-determined questions, instructions for asking, one or more times during a time interval, a subset of pre-determined questions in the set of pre-determined questions, instructions for receiving, one or more times during the time interval, answers to the subset of pre-determined questions, and instructions for receiving configuration instructions. The configuration instructions may select the subset of pre-determined questions that are asked.

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Katonah, NY, United States of America

Lawrence C Newman