Connective Tissue Imagineering, LLC

Mrs, LLC

Lawrence B Sandberg

Thomas Mitts

Philip J Roos

Felipe Jimenez, Jr

Thomas F Mitts

Compositions used to enhance the elasticity and/or appearance of tissue are described. The compositions include peptides and/or peptide-like compounds and combinations thereof having low molecular weights and which substantially correspond to sequences found in elastin. The compositions may be applied to human skin in a cosmetic or therapeutic formulation and may result in enhanced elasticity and turgor of the skin.

Elastin peptide analogs and uses thereof

The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides or peptide-like compounds having low molecular weights and which substantially correspond to sequences found in elastin. The present composition specifically includes chemical modification of the peptides described herein, specifically carboxy and amino modification including the addition of amino acids to either end of the peptide fragments.

The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides having low molecular weights and which substantially correspond to sequences found in elastin. These peptides are used in conjunction with or in combination with retinoids, preferably tretinoin.

Elastin peptide analogs and uses of same incombination with skin enhancing agents

Asparagine containing elastin peptide analogs

The present invention is directed to a composition and method for enhancing the appearance of skin or tissue. The invention is preferably a combination of elastin-derived peptides and steroidal compounds useful in the treatment of problems associated with deficient elastin or conditions that would benefit from increased elastin.

Cosmetic or dermatological use of 7-hydroxylated steroids in combination with elastin derived peptides

The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides having low molecular weights and which substantially correspond to sequences found in elastin More preferably, the present invention corresponds to the general formula R -Leucine-Glycine-Alanine-Glycine-Glycine-Alanine-Glycine-R .

Elastin peptide analogs and methods of using same

The present invention is directed to a formulation or composition which is used to enhance the softness, elastin, or appearance of tissue by increasing the endogenous elastin production. Specifically, the present invention is directed to a composition formulated from the products of thermolysin digestion which are filtered through a 10,000 molecular weight cutoff device, which may be dried to have a formulation which contains 90% or greater of peptides having a molecular weight lower than 10,000 Da. This formulation is preferably applied to human skin in a cosmetic or therapeutic formulation and results in enhanced elasticity of the skin.

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Colton, CA, United States of America

Lawrence B Sandberg