Warsaw Orthopedic, Inc.

Osteotech, Inc.

Cap Biomaterials, LLC

Progenica Therapeutics, LLC

Lawrence A Shimp

Todd M Boyce

David R Kaes

John Winterbottom

John W Morris

Guobao Wei

David Knaack

Albert Manrique

Nelson L Scarborough

John W Boyle

Keyvan Behnam

Erik O Martz

Daryl R Sybert

Nels J Lauritzen

James L Russell

Cristy Richards

Kenneth C Petersen

Jean T Edwards

Scott D Boden

Michael Dowd

Hsiu Ying Sherry Wang

Nanette Forsyth

Kathy Traianedes

Abdulhafez A Selim

Mark P Daugherty

Brent S Mitchell

Abdulhafez A Selem

Robert Cohen

Mohamed Attawia

Randal R Betz

Fred H Geisler

Jo-Wen Lin

James Beisser

Daniel E Rosenthal

Michele Diegmann

Michael L Jaffe

Alexander R Vaccaro

Subhabrata Bhattacharyya

Arthur A Alfaro

Michael F O'Brien

William G Hubbard

Harvinder Sandhu

Munish Chandra Gupta

Mark DeCaro

Christina Mossaad

Perry Geremakis

Steven Annunziato

Ryan Belaney

Charles M Schiff

Alexis P Shelokov

Sherry Hsiu-Ying Wang

Jennifer Grasso

Robert Waterman

Robert P Skinner

Sheldon Dean

Daniel Martins

Keith A Orlowski

Abdulhafez Abdulwahed Abdulhafez

Helen Newman

Mark P Daughterty

Howard J Luks

Carl R Schwarz

Martin O Ouko

John M Winterbottom

Sheldon W Iii Dean

Brent Mitchell

Timothy R Miller

Cristy J Richards

Bone void filler compositions and methods for preparation to provide substrates with carbonate surface coatings to promote bone growth.

Methods for carbonate surface coating and related bone void filler compositions

Described herein are compositions comprising a BMP-2 derived peptide conjugated to albumin for use in bone grafts. The composition may further include bone matrix, such as demineralized bone matrix (DBM).

Surface enhanced demineralized bone graft material

Methods for preparing bone void filler substrates with carbonate surface coatings to promote bone growth.

The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.

Collagen matrix for cell therapy

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

Polyurethanes for osteoimplants

Methods for making a biodegradable collagen matrix having increased osteoinductivity and a biodegradable collagen matrix prepared by these methods are provided. In various embodiments, the methods include providing an acidic collagen slurry and mixing it with at least one water soluble and/or hydrophilic bioactive agent under conditions sufficient to cause the collagen slurry to self-assemble into macroscopic collagen fibers and cause the at least one bioactive agent to form a collagen matrix containing the bioactive agent. Conditions sufficient to cause the collagen slurry to self-assembly include raising the pH of the slurry to from about 5 to about a pH of 9 and/or adding bone powder, calcium phosphate, hydroxyapatite, DBM or a mixture thereof to the acidic collagen slurry in order to raise the pH from about 5 to about 9.

Collagen matrix

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.

Segmented delivery system

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

Delivery system attachment

Carbonated calcium phosphate compositions and methods of preparation, affording enhanced biophysical properties.

Composites of hydroxyapatite and calcium carbonate and related methods of preparation and use

An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.

Osteoimplant and method of making same

Methods for forming implantable compositions are provided. In some embodiments, the methods include (i) providing a gel base, (ii) adding water and a hydrating agent to the gel base to form a mixture, (iii) reducing the water content of the mixture; and (iv) adding a delivered material before, during, and/or after step (ii) or (iii). The water content is reduced to about 5% or less by weight of the implantable composition.

Implantable compositions and methods for preparing the same

Foam-formed collagen strands and methods for forming strands involve depositing a dispersed solution of an isolated cleaned, de-fatted, enzymatically-treated (or non-enzyme treated) human-derived collagen product having a preserved amount of its natural constituents into grooves of a grooved plate, and processing the dispersed collagen product to provide a foam-formed collagen strand. Foam-formed collagen strands may be processed into threads having a matrix of reticulated pores to conduct biological materials in and through the strand, the collagen of the collagen strand comprising isolated, enzymatically-treated human derived collagen having a preserved amount of its natural collagen constituents.

Foam-formed collagen strand

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Morganville, NJ, United States of America

Lawrence A Shimp