Bruker Biospin Gmbh

Carestream Health, Inc.

Laurie L Voci

Gilbert Feke

Apparatus and method for performing depth sectioned fluorescence imaging of a turbid sample including a fluorescent turbid medium, uses an apparatus for quantitative modulated fluorescence imaging, the apparatus including projection optics with a first optical axis, to expose the turbid sample to a periodic pattern of excitation radiation to provide depth-resolved discrimination of fluorescent structures within the turbid medium; an image capture module, including a second optical axis and a detection beam path, to receive a data image from the sample; and a signal processor to transform the data image from the sample, spatially filter the transformed data image from the sample, and reconstruct the filtered, transformed data image from the sample.

Apparatus and method for fluorescence imaging and tomography using spatially structured illumination

An imaging system for imaging an object. More specifically, an imaging system enabling depth sectioned fluorescence imaging in a turbid medium, such as human or animal tissue, to substantially minimize the excitation radiation from reaching the detection beam path. The imaging system includes an arrangement of the excitation radiation source wherein the optical axis of the source is inclined relative to the optical axis of the camera, the optical plane of the source and the optical plane of the object are subject to a Scheimpflug condition, and the angle of inclination of the source is selected such that the excitation radiation incident upon the object is reflected to minimize excitation radiation from reaching the detection beam path.

An apparatus and method for depth selected fluorescence measurements is provided. The apparatus may include a carrier for at least one sample substance; projection optics; an image capture module; a signal processor to transform the data image to provide depth selected fluorescence measurement for the at least one sample substance. The apparatus is arranged such that a first optical axis is inclined relative to a second optical axis so that the projection optics have an angle of inclination relative to the image plane. The angle of inclination is selected so that a component of excitation radiation incident upon, but not absorbed by, the at least one sample substance is scattered or reflected to reduce excitation radiation from reaching the detection beam path.

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Victor, NY, United States of America

Laurie L Voci