Upm-kymmene Corporation

Lauri Paasonen

Markus Nuopponen

Anne Meriluoto

Kari Luukko

Marjo Yliperttula

Arto Merivaara

Elle Koivunotko

Harri Jukarainen

Tero Satomaa

Sami Valkonen

Isko Kajanto

Jari Helin

Mika Kosonen

Mikael Skurnik

Tuula Heinonen

Lindsay Davies

Saara Laitinen

Kalle Manninen

Ossi Korhonen

Jacopo Zini

Lisa Chinello

Susanna Narkilahti

Marika Mannerström

Sheetal Patpatia

Tarja Toimela

Tiina Joki

Saija Kiljunen

Laura Ylä-Outinen

Giulia Scapin

Jukka Rissanen

Olli Aitio

A method for freeze-drying a hydrogel composition is disclosed, the method comprising providing the hydrogel composition, wherein the hydrogel composition comprises cellulose nanofibrils and/or cellulose nanocrystals, at least one saccharide, at least one amino acid, and biologics; and freeze-drying the hydrogel composition, thereby obtaining a freeze-dried hydrogel composition.

Method for freeze-drying a hydrogel composition and a freeze-dried hydrogel composition

The present disclosure relates to a method for controlling freeze-drying of a hydrogel wherein the method comprises adjusting the residual water content of the freeze-dried hydrogel, and to a freeze-dried hydrogel composition comprising nanoscale cellulose and a at least one biomolecule selected from an oligosaccharide or a disaccharide. The present disclosure further concerns the use of the freeze-dried hydrogel composition for cell culturing, a cell culturing scaffold as well as a process for manufacturing a reconstituted hydrogel.

Controlling freeze-drying of a hydrogel

A cell culture plate includes one or more cell culture well(s) including at least one barrier for dividing the well into at least two compartments, wherein the barrier includes nanofibrillar cellulose hydrogel, and a method for the preparation thereof. A method for detecting a substance is also disclosed.

Cell culture plate, method for preparing thereof and method for detecting a substance

The present invention is related to methods and materials for culturing expanding cells in a three-dimensional culture. The material comprises plant-derived anionic nanofibrillar cellulose, wherein the anionic nanofibrillar cellulose is in a form of hydrogel. The invention also provides methods for producing materials and compositions comprising plant-derived anionic nanofibrillar cellulose.

Supportive nanofibrillar cellulose scaffold for expanding cells

The present application relates to a method for preparing a medical product, the method comprising providing an aqueous dispersion of nanofibrillar cellulose, providing a nonwoven fabric, immersing the nonwoven fabric in the aqueous dispersion of nanofibrillar cellulose to form a coating on the nonwoven fabric, passing the immersed nonwoven fabric through a prefined gap to define the thickness of the coating on the immersed nonwoven fabric without pressing, and dewatering the immersed nonwoven fabric, to obtain the medical product. The present application also relates to a medical product comprising a supporting layer and an absorbent layer, wherein the supporting layer comprises a nonwoven fabric, and the absorbent layer comprises unpressed nanofibrillar cellulose having an average fibril diameter of 200 nm or less, wherein the absorbent layer is coating the supporting layer.

Medical product and method for preparing thereof

An injectable pharmaceutical formulation includes nanofibrillar cellulose hydrogel wherein the content of nanofibrillar cellulose in the pharmaceutical formulation is the range of 1-8% (w/w), and pharmaceutical compound. The injectable pharmaceutical formulation can provide a sustained release of a pharmaceutical compound in a subject. Use of nanofibrillar cellulose for preparing the injectable pharmaceutical formulation is also disclosed.

Injectable pharmaceutical formulation

A composition or matrix comprising a bacteriophage and nanofibrillar cellulose or a derivative thereof in a wet or dry state is disclosed.

Composition or matrix for storage of bacteriophages comprising nanofibrillar cellulose

The invention relates to a method for reducing the viscosity of a nanofibrillar cellulose hydrogel, wherein the method comprises mixing a nanofibrillar cellulose hydrogel with an aqueous growth medium for cell culture, wherein the aqueous growth medium contains one or more salts and optionally one or more sugars, using shearing forces so that a homogeneous dispersion is formed. The invention further relates to a dispersion comprising a nanofibrillar cellulose hydrogel and an aqueous growth medium for cell culture and to a use of an aqueous growth medium.

Method for reducing the viscosity of a nanofibrillar cellulose hydrogel

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Järvenpää, Finland

Lauri Paasonen