Pierre Fabre Dermo-cosmetique

Pierre Fabre Medicament

Laurent Subra

Philippe Joulia

Christel Fiorini-Puybaret

Marc Nicolas

Hélène Duplan

Paul Hellier

Christel Fiorini Puybaret

Jean-Marie Autret

Catherine Diard

Carine Jacques-jamin

Helene Duplan

Carine Jacques-Jamin

The present disclosure relates to a process for preparing aextract which is rich in Lawsone. It also relates to the extract which may be obtained by said process and to a composition comprising thereof. The disclosure also relates to a method for dying fibers, in particular keratin fibers.

Process for preparing aextract

The invention relates to an extract of the aerial parts of, as well as its preparation method and the extract that can be obtained by said method. The invention also relates to a cosmetic dye composition comprising such an extract. The invention finally concerns a cosmetic method for dying keratin fibers comprising the application of such a composition.

Extract of the aerial parts ofand its preparation method

The present invention relates to a method for synthesizing a pharmaceutically acceptable acid addition salt of (1S, 2R)-milnacipran comprising the following successive steps: (a) reaction of phenylacetonitrile and of (R)-epichlorhydrin in the presence of a base containing an alkaline metal, followed by a basic treatment, and then by an acid treatment in order to obtain a lactone; (b) reaction of said lactone with MNEt, wherein M represents an alkaline metal, or with NHEtin the presence of a Lewis acid-amine complex, in order to obtain an amide-alcohol; (c) reaction of said amide-alcohol with thionyl chloride in order to obtain a chlorinated amide; (d) reaction of said chlorinated amide with a phthalimide salt in order to obtain a phthalimide derivative; (e) hydrolysis of the phthalimide group of said phthalimide derivative in order to obtain (1S, 2R)-milnacipran, and (f) salification of (1S, 2R)-milnacipran in a suitable solvent system in the presence of a pharmaceutically acceptable acid.

Method for synthesis of (1S, 2R)-milnacipran

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Montgaillard, France

Laurent Subra