Deuteria Beverages, LLC

Dsm IP Assets B.v.

Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg

Qpex Biopharma, Inc.

Dms IP Assets B.v.

Laurent Lefort

Jonathan Alan Medlock

Mike Schmitkamp

Johannes Gerardus De Vries

Werner Bonrath

Matthias Beller

Sandra Hinze

Pim Puylaert

Andreas H M De Vries

Richard Van Heck

Mae Joanne Aguila

Yuting Fan

Guenter Pappenberger

Scott J Hecker

Serge H Boyer

Hans-Peter Hohmann

Gerhard Steinbauer

Ulfried Felfer

Martina Kotthaus

Hubertus J A Dielemans

Jeroen Boogers

Angela Gonzalez De Castro

Hans Peter Hohmann

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, &#x3b2;-lactamase inhibitors (BLIs).

Boronic acid derivatives and synthesis thereof

The present invention relates to a selective reduction of specific aldehydes and ketones to their corresponding alcohols.

Selective reduction of aldehydes and ketones

The invention relates to a process for the preparation of a deuterated ethanol from ethanol, DO, a ruthenium catalyst, and a co-solvent.

Process for the preparation of deuterated ethanol from DO

The invention relates to a process for the preparation of a deuterated ethanol from an acetic acid, an acetate, or an amide by reaction with Din the presence of a transition metal catalyst.

Process for the preparation of deuterated ethanol from D2

The present invention relates to a novel and inventive process for the production of sorbitol from D-sucrose.

Production of D-sorbitol by hydrogenation

The present invention relates to a selective reduction of esters to their corresponding alcohols.

Selective reduction of esters to alcohols

The present invention relates to a new process for the production of D-sorbitol.

Process for production of D-Sorbitol

A process for transition metal-catalyzed, asymmetric hydrogenation of acrylic acid derivatives of the formula (I) in which R1 is H or an optionally substituted alkyl, aryl or heteroaryl radical, R2 is an optionally substituted alkyl, aryl or heteroaryl radical, and R3 is H or a C-C-alkyl radical, which comprises hydrogenating compounds of the formula (I), optionally in a solvent, in the presence of one or more hydrogen donors, using a catalyst system which comprises a transition metal from the group of ruthenium, rhodium and iridium and a combination of a chiral phosphorus ligand of the formula (II) in which Cn, together with the two oxygen atoms and the phosphorus atom, forms an optionally substituted ring having from 2 to 6 carbon atoms and R4 is an optionally substituted alkyl, aryl, alkoxy or aryloxy radical or NR5R6 where R5 and R6 may each independently be H or an optionally substituted alkyl, aryl, aralkyl or alkaryl radical, or, together with the nitrogen atom, may form a ring, and an achiral phosphine ligand of the formula (III) in which R is an optionally substituted alkyl or aryl radical, to the corresponding compounds of the formula (IV) in which R1, R2 and R3 are each as defined above, and also a novel catalyst system for asymmetric transition metal catalysis.

Process for transition metal-catalyzed asymmetric hydrogenation of acrylic acid derivatives, and a novel catalyst system for asymmetric transition metal catalysis

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Maastricht, Netherlands

Laurent Lefort