Firmenich Sa

Firemenich Sa

Laurent Kermorvan

Philippe Dupau

Lucia Bonomo

Murielle Haldimann Sanchez

Described herein are catalytic hydrogenation processes, using Ru complexes with tetradentate ligands of formula L in hydrogenation processes for the reduction of ketone, aldehyde, ester, or lactone into the corresponding alcohol or diol respectively. These processes use a ruthenium complex of formula (1) as defined herein.

Hydrogenation of carbonyls with tetradentate PNNP ligand ruthenium complexes

The present invention relates to processes for the reduction by hydrogenation, using molecular H, of a C-Csubstrate containing one or two aldehydes functional groups into the corresponding alcohols or diol, characterized in that said process is carried out in the presence of &#x2014;at least one catalyst or pre-catalyst in the form of a ruthenium complex having a coordination sphere of the NPO, wherein the coordinating atom N and one coordinating atom P are provided by a first bidentate ligand, and the two other coordinating atoms Pare provided by a second bidentate ligand and the coordinating atoms Oare provided by two non-linear carboxylate ligands; and &#x2014;optionally of an acidic additive.

Selective hydrogenation of aldehydes with Ru/bidentate ligands complexes

The present invention relates to processes for the reduction by hydrogenation, using molecular H, of a C-Csubstrate containing one or two aldehydes functional groups into the corresponding alcohol or diol, characterized in that said process is carried out in the presence of &#x2014;at least one catalyst or pre-catalyst in the form of a ruthenium complex having a coordination sphere of the NPO, wherein the coordinating atoms Nare provided by a first bidentate ligand, the coordinating atoms Pare provided by a second bidentate ligand and the coordinating atoms Oare provided by two non-linear carboxylate ligands; and&#x2014;optionally of an acidic additive.

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Geneva, Switzerland

Laurent Kermorvan