Sanofi-aventis

Sanofi

L'oreal

Sanofi-synthelabo

Laurent Dubois

Yannick Evanno

Andre Malanda

Catherine Gille

David Machnik

André Malanda

Luc Even

Mireille Sevrin

Christian Maloizel

Nathalie Rakotoarisoa

Vincent De Laforcade

Jacques Froissant

Odile LeClerc

Frank Marguet

Fanny Guillaumat-Louvard

Andrè Malanda

R&eacute;gine Bartsch

Yannick c/o Sanofi-Aventis Département Brevets Evanno

The invention concerns compounds of general formula (I), wherein n, X, X, X, X, Y and W are as defined herein.  The invention also concerns a method for preparing said compounds and their therapeutic use.

N-(Heteroaryl)-1-heteroarylalky1-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof

The invention relates to compounds of the general formula (I): Wherein X, Y, Z, Z, Z, Z, Zand n are as defined herein. The invention also relates to a method for making the same and to the use thereof in therapy.

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The disclosure relates to compounds of formula (I): wherein X, X, X, X, Y, n, A, and W are as defined in the disclosure, or a salt thereof, or a hydrate or solvate thereof, and to processes for the preparation of these compounds and the therapeutic use thereof.

Bicyclic derivatives of azabicyclic carboxamides, preparation thereof and therapeutic use thereof

The invention concerns compounds of general formula (I): Wherein n, X, X, X, X, Y, Z, Z, Z, Zand Zare as defined herein. The invention also concerns a process for the preparation of compounds of formula (I) and their therapeutic use.

N-(Aminoheteroaryl)-1H-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof

The invention relates to compounds of general formula (I): Wherein n, X, X, X, X, Y, Z, Z, Z, Z, Ra and Rb are as defined herein. The invention also relates to process for the preparation of compounds of formula (I) and their therapeutic use.

N-(aminoheteroaryl)-1H-indole-2-carboxamide derivatives, preparation thereof and therapeutic use therof

The invention relates to tricyclic N-heteroaryl-carboxamide derivatives having the formula (I): Wherein A, P, W, Z, Z, Z, Z, Z, Z, Z, Z, Rand R' are as described herein. The invention also relates to a method for preparing the same and to the therapeutic use thereof.

Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof

This disclosure relates to compounds of formula (I): wherein G, G, G, G, n, Y, Z, Z, Z, Z, and Zare as defined in the disclosure, or a salt thereof, or a hydrate or solvate thereof, and to processes for the preparation of these compounds and the therapeutic use thereof.

Derivatives of indole-2-carboxamides and of azaindole-2-carboxamides substituted with a silanyl group, preparation thereof and therapeutic use thereof

This disclosure relates to compounds of formula (I): wherein X, X, X, X, n, Y, W, and A are as defined in the disclosure, or a salt thereof, or a hydrate or solvate thereof, and to processes for the preparation of these compounds and the therapeutic use thereof.

N-azabicyclic carboxamide derivatives, preparation thereof and therapeutic use thereof

The disclosure relates to compounds of formula (I): wherein X, X, X, X, Z, Z, Z, Z, Ra, Rb, n, Y, and W are as defined in the disclosure, or a salt thereof, or a hydrate or solvate thereof, and to processes for the preparation of these compounds and the therapeutic use thereof.

Azabicyclic carboxamide derivatives, preparation thereof and therapeutic use thereof

The invention concerns tricyclic N-heteroaryl-carboxamide derivatives containing a benzimidazole unit of general formula (I): Wherein A, P, Y, R, Rand Rare as defined herein. The invention also concerns a method of preparing the compounds and their therapeutic use.

Compounds corresponding to the formula (I) as defined in the disclosure, as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.

2H or 3H-benzo[E]indazol-1-YL carbamate derivatives, the preparation and therapeutic use thereof

The invention relates to compounds of general formula (I):  Wherein n, X, X, X, X, Y, Z, Z, Z, Z, Ra and Rb are as defined herein. The invention also relates to process for the preparation of compounds of formula (I) and their therapeutic use.

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Le Plessis-Robinson, France

Laurent Dubois