Brown University

Women & Infants' Hospital

Women and Infants' Hospital Rhode Island

Louisiana State University and Agricultural & Mechanical College

Women & Infants Hospital of Rhode Island

Laurent Brard

Rakesh Kumar Singh

Satyan Kalkunte

Kyu Kwang Kim

Giselle L Saulnier Sholler

Narasimha Swamy

Robert Michael Strongin

Stayan Kalkunte

Onur Alpturk

Giselle Saulnier-Sholler

Hema Malini Sundaresha

The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.

Nitrofuran compounds for the treatment of cancer and angiogenesis

This invention relates to the design, synthesis and use of synthetic vitamin D and other steroidal analogs. It further relates to the therapeutic use of such analogs and their manufacture.

Heterocycles and derivatives thereof and methods of manufacture and therapeutic use

The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds. 

This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.

Organometallic complexes as therapeutic agents

This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufacture and use.

N-amino tetrahydrothiazine derivatives, method of manufacture and use

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Cranston, RI, United States of America

Laurent Brard