Merial Limited

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Boehringer Ingelheim Animal Health USA Inc.

Boehringer Ingelheim Animal Heatlh USA Inc.

Laurent Bernard Fischer

Jesus G Valenzuela

Jean-Christophe Francis Audonnet

Shaden Kamhawi

Nicolas Pierre Yves Carboulec

Fabien Lux

Simona Barzu-Le-Roux

Jose Ribeiro

Shaden Kamahwi

Hamide Aslan Suau

Yasmine Belkaid

Yovany Moreno

Cecile Sigoillot-Claude

Frederic Beugnet

Jose M C Ribiero

Francis Milward

Simona Barzu-Leroux

The present invention encompasses a vaccine composition and method of use for treating heartworm infestation in mammals. The vaccine composition includes chimeric antigens engineered and manufactured using the genetic code (i.e., the amino acid or protein sequence) of the target sequence. After introduction of the vaccine composition containing the target antigen into the host (e.g., a canine), the host will generate antibodies as part of its robust immune response to the antigen. As the antibodies circulate through the host's plasma, heartworm larvae will consume the antibodies as they feed on the plasma. The antibodies will then act on internal targets of the worm recognized as antigens.

Heartworm vaccine, methods and uses thereof

The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.

Expression of chimeric KSAC protein and method of producing soluble proteins by high pressure

The application discloses therapeutic vaccines based upon the 'pING' DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.

Her2 DNA vaccine as adjunct treatment for cancers in companion animals

The present invention provides vectors that contain and express in vivo or in vitro sand flysalivary antigens that elicit an immune response in animal or human against, vaccine compositions comprising said vectors and/orsalivary polypeptides, methods of vaccination against, and kits for use with such methods and compositions.

Leishmania vaccine using sand fly salivary immunogen

The present invention provides a method for effectively and reproducibly infecting canines withusing sand flies to vector the parasite. The inventive method comprises several steps, including ensuring canines are na&#xef;ve to, infecting the canines using bites of-infected sand fly bites, and evaluating successful transmission of theparasites.

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The present invention provides vectors that contain and express in vivoKMP11 or an epitope thereof that elicits an immune response in a dog against, compositions comprising said vectors, methods of vaccination against, and kits for use with such methods and compositions.

Canine leishmania vaccine

Leishmania challenge model

The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.

Plasmid encoding feline BMP-7

Plasmid encoding human BMP-7

Substantially purified salivaryandpolypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including theandpolynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating or preventingare disclosed.

DNA vaccine against a pathogen affecting farm animals, in particular bovines or porcines, comprising a plasmid containing a nucleotide sequence encoding an immunogen of a pathogen of the animal species considered, under conditions allowing the in vivo expression of this sequence, and a cationic lipid containing a quaternary ammonium salt, of formula in which R1 is a saturated or unsaturated linear aliphatic radical having 12 to 18 carbon atoms, R2 is another aliphatic radical containing 2 or 3 carbon atoms, and X a hydroxyl or amine group, this lipid being preferably DMRIE.

Growing community of inventors

Saint Foy les Lyon, France

Laurent Bernard Fischer