Centre National De La Recherche Scientifique

Assistance Publique-hopitaux De Paris

Université Paris Diderot-paris 7

Occlugel

Anglo Platinum Limited

Institut Gustave Roussy

Université Paris-saclay

Université Paris-sud 11

Universite Paris Cité

Laurence Moine

Alexandre Laurent

Michel Wassef

Laurent Bedouet

Richard Alasdair Grant

David Colin Sherrington

Denis Labarre

Emeline Servais

Stephanie Louguet

Valentin Verret

Elias Fattal

Nicolas Tsapis

Stéphanie Louguet

Khelil Slimani

Frédéric Deschamps

Van Nga Nguyen

Thierry De Baere

Lambros Tselikas

Nicolas Huang

Thomas Isoardo

Minh Tam Baylatry

Anouk Bisdorf-Bresson

Jean-Pierre Saint-Maurice

The present invention relates to a water-in-oil emulsion comprising a continuous oil phase and an aqueous phase dispersed in the form of drops, the said aqueous phase comprising polyester-based nanoparticles and at least one therapeutic agent.

Injectable water-in-oil emulsions and uses thereof

The present invention relates to a macromolecule-loaded bioresorbable crosslinked polymer wherein the polymer is obtainable from the polymerization of: (i) at least one monomer of formula (I) (CH&#x2550;CR)CO&#x2014;K wherein: &#x2014;K represents O&#x2014;Z or NH&#x2014;Z, Z representing (CRR)&#x2014;CH, (CH&#x2014;CH&#x2014;O)&#x2014;H, (CH&#x2014;CH&#x2014;O)&#x2014;CH, (CH)&#x2014;NRRwith m representing an integer from 1 to 30; &#x2014;R, R, R, Rand Rindependently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, and wherein the macromolecule is chosen in the group consisting of proteins and nucleic acids.

Implantable bio-resorbable polymer charged with fragile macromolecules

The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH&#x2550;CR)CO&#x2014;K (I) wherein: K represents 0-Z or NH&#x2014;Z, Z representing (CRR)&#x2014;CH, (CH&#x2014;CH&#x2014;O)&#x2014;H, (CH&#x2014;CH&#x2014;O)&#x2014;CH, (CH)&#x2014;NRRwith m representing an integer from 1 to 30; R, R, R, Rand Rindependently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker.

Implantable bio-resorbable polymer

The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH&#x2550;CR)CO&#x2014;K (1) wherein: &#x2014;K represents O&#x2014;Z or N H&#x2014;Z, Z representing (CRR)m-CH, (CH&#x2014;CH&#x2014;O)m-H, (CH&#x2014;CH&#x2014;O)m-CH, (CH)m-NRRwith m representing an integer from 1 to 30; &#x2014;R, R, R, Rand Rindependently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: &#x2014; R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; &#x2014;i and j represent independently an integer chosen between 0 and 2; &#x2014;X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C&#x2014;C and (iii) at least one bio-resorbable block copolymer cross-linker. 

Implantable swellable bio-resorbable polymer

An injectable biomaterial containing a non-aqueous solvent suitable for injection to a human being and nanoparticles made of a polymer that is insoluble in water and insoluble in the non-aqueous solvent, in which the nanoparticles are loaded with a drug or a biological agent. The injectable biomaterial is suitable for occluding normal or malformative blood vessels or non-circulating cavities, or for necrosing tumors.

Injectable biomaterial

A process for the chromatographic interseparation of rhodium in admixture with at least one base metal from a feed solution includes complexes of these metals. The process includes contacting the solution with at least one chromatographic medium, and eluting one or more fractions such that at least one fraction includes rhodium complex substantially free from base metal contamination. The at least one chromatography medium includes a support functionalized with substituted amine groups which further include at least one hydrophilic group. Other platinum group metals can also be separated, both from one another and from base metals.

Separation of platinum group metals

A process for the chromatographic interseparation of rhodium in admixture with at least one base metal from a feed solution comprising complexes of these metals. The process comprises contacting the solution with at least one chromatographic medium, and eluting one or more fractions such that at least one fraction comprises rhodium complex substantially free from base metal contamination. The at least one chromatography medium comprises a support functionalised with substituted amine groups which further comprise at least one hydrophilic group. Other platinum group metals can also be separated, both from one another and from base metals.

Growing community of inventors

Saint Cloud, France

Laurence Moine