Centre National De La Recherche Scientifique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Institut Curie

Université Paris Sud-paris Xi

Laurence Lafanechère

Sylvain Rault

Christian Rivalle

Caroline Barette

Renaud Prudent

Patrick Dallemagne

Peggy Suzanne

Eric Denarier

Audrey Vernet

Serge Perato

Emilie Vassal

Aurélien Lesnard

Marc Billaud

ChiHung Nguyen

Jean-charles Lancelot

Lauralie Peronne

The invention concerns a compound of formula (I), Formula (I), wherein R, Rand Rare independently selected form the group consisting of: —a hydrogen atom, —a halogen atom, —an alkyl group, linear, cyclic or branched, saturated or unsaturated, possibly substituted, comprising from 1 to 10 carbon atoms, —an acyl group comprising from 1 to 10 carbon atoms, —a carboxyl group, —an amido group comprising from 1 to 10 carbon atoms, and —an imino group, possibly substituted by an alkyl group, linear, cyclic or branched, saturated or unsaturated, and wherein R, R, Rand Rare independently selected form the group consisting of: —a hydrogen atom, —a halogen atom, —a hydroxyl group, —an alkyl group, linear, cyclic or branched, saturated or unsaturated, possibly substituted, comprising from 1 to 10 carbon atoms, —an alkoxy group comprising from 1 to 10 carbon atoms, —an acyl group comprising from 1 to 10 carbon atoms, —a carbonate group from 1 to 10 carbon atoms, —a carboxyl group, and —a cyano group.

Carbazole derivatives sensitizing cells to anti-cancer agents

Pyridocarbazole-type compounds of formula (I): are provided as a medicament, and more particularly for application in anticancer chemotherapy. Also provided is a pharmaceutical composition with the compound and methods for preventing and/or treating neurodegenerative-type pathologies, such as Alzheimer's disease and schizophrenia, parasitoses, such as malaria, or glaucomas.

Pyridocarbazole type compounds and applications thereof

Growing community of inventors

Grenoble, France

Laurence Lafanechère