Other

American Cyanamid Company

Boehringer Ingelheim Pharmaceuticals, Inc.

Boehringer Ingelheim International Gmbh

Cytec Technology Corporation

Nepera Chemical Co.

Laurence John Nummy

Li Feng Zhang

Jun Wang

Chris Hugh Senanayake

Richard John Varsolona

Rogelio Perez Frutos

Dhileepkumar Krishnamurthy

Xiao-Jun Wang

Weitong Dong

Thomas Nicola

Zhulin Tan

Jon Charles Lorenz

Sonia Rodriguez

Thomas Gabriel Tampone

Thomas Wirth

Jutta Kroeber

Yibo Xu

Allan M Feldman

Jason Brazzillo

Steven L Trenbeath

Vazken A Alexanian

Joshua Daniel Sieber

Pengtao Zhang

Magnus C Eriksson

Jolaine Savoie

Kanwar Pal Singh Sidhu

Phouvieng Beyer

Diana Reeves

Joshua D Sieber

Denis P Byrne

Jason A Brazzillo

Magnus Eriksson

June Wang

The present invention relates to compounds of (II) and an acceptable salt or hydrate thereof method of making same. 

Intermediate compounds and methods

Disclosed is a multi-step process for preparing a compound of Formula I: wherein Rto Rare as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.

Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides

A process for preparing oxiranemethane derivatives which are useful as intermediates for preparing aspartyl protease inhibitors comprising the steps of activating an aminodiol, acylating the aminodiol and reacting the acylated aminodiol with a base to form an epoxy compound.

Process for preparing oxiranemethanamine derivatives

A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of the formula: ##STR1## wherein R1 is a linear, branched or cyclic hydrocarbon of from one to eight carbon atoms, optionally substituted with one or more electron stabilizing groups, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.

Method for the preparation of 3-amino-2-chloro-4-alkylpyridines

Novel bicyclic alkyl dicarbamates are prepared from norbornadiene and other simple starting materials, and these are subsequently thermally cracked to novel diisocyanate norbornyl derivatives, which are, among others, useful for crosslinking active hydrogen compounds.

Preparation of a novel diisocyanate from norbornadiene

A process is disclosed whereby mono- and diurethane cyclohexyl derivatives are obtained corresponding to the Lewis acid-catalyzed addition reaction of dipentene and methyl carbamate at a temperature of from about 40.degree. to about 150.degree.C. The mono- and diurethane cyclohexyl derivatives are pyrolytically converted to other corresponding mono- and diisocyanate cyclohexyl derivatives. Novel vinyl unsaturated monoisocyanate cyclohexyl derivatives useful as reactants for polyfunctional compounds to produce cured compositions are disclosed.

Preparation of cyclohexyl mono- and diurethanes and isocyanates derived

A process for preparing a 4-substituted pyridine product from a starting pyridine substituted in the 4-position by a leaving group susceptible to nucleophilic displacement when the starting pyridine is in quaternized form, comprises,

Preparation of 4-substituted pyridines using quaternary pyridine salts

A process for producing aromatic mono- and polyisocyanates by the addition reaction of isocyanic acid with vinyl aromatics is disclosed. The process is characterized by the slow addition of the olefin to a reaction mass of solvent and isocyanic acid to maintain the isocyanic acid in high excess to unreacted olefin.

Manufacture of isocyanates

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Newburgh, NY, United States of America

Laurence John Nummy