Sorin Crm Sas

Institut National De La Sante Et De La Recherche Medicale

Université De Rennes 1

Université Joseph Fourier

Ela Medical S.a.

Ela Medical S.a.s.

Université Joseph Fourier - Grenoble 1

Universite Rennes 1

Université Grenoble Alpes

Inserm (institut National De La Sante Et De La Recherche Medicale)

Laurence Graindorge

Alfredo Hernandez

Amel Amblard

Jean-Louis Pépin

Marcel Limousin

Christine Henry

Delphine Feuerstein

Laure Duchemin Laporte

Marie-Anne Euzen

Elodie Vincent

Marie-Anen Euzen

A device for treating sleep apnea by discriminating between successive sleep stages of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, a sensor configured to measure a biological parameter of the patient, and a controller. The controller is configured to determine a state of the patient based on the biological parameter, perform a sleep analysis based on the state of the patient, activate the generator to trigger production of the stimulation pulses, determine a variation of the biological parameter subsequent to the production of the stimulation pulses, determine a response of the patient to the stimulation pulses according to the variation of the biological parameter, and determine a sleep stage of the patient based on the response.

Device for discrimination of stages of a patient's sleep

A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a cessation of the respiratory disorder. The processor is further configured to extend the stimulation control signals for a determined duration following the cessation of the respiratory disorder.

System for respiratory disorder therapy with stabilization control of stimulation

A device includes a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.

Device for optimization of sleep apnea syndrome therapy by kinesthetic stimulation

A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.

System for respiratory disorder therapy with selection of stimulation strategies

A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient.

Device for the treatment of sleep apnea syndrome in a patient by kinesthetic stimulation

Devices and methods for providing pacing in multiple modes are provided. One device operates in a dual chamber (DDD or biventricular) mode and in a pacing mode favoring the spontaneous atrioventricular conduction such as an AAI mode () with a ventricular sensing or a mode with hysteresis of the atrioventricular delay. The device controls (-) the conditional switching from one mode to the other. The device comprises a hemodynamic sensor, including an endocardial acceleration sensor, derives a hemodynamic index representative of the hemodynamic tolerance of the patient to the spontaneous atrioventricular conduction. The device controls inhibiting or () forcing the conditional switching of the device to the DDD (or biventricular) mode according to the evolution of the hemodynamic index.

Stimulation mode determination

A device produces at least two distinct temporal components (V, V) from two separate endocardial electrogram EGM signals concurrently collected in the same cavity. A 2D non-temporal characteristic is determined from the variations of one of the temporal components (V) versus the other (V). The analysis of this characteristic allows detection of the possible presence of an anodal stimulation, causing a depolarization in a second cavity after stimulation delivered to a first heart chamber, opposite to the first. One possibility is to proceed by observing whether the non-temporal 2D characteristic is included or not within a predetermined domain defined in a coordinate frame corresponding to the space of the two temporal components.

Active implantable medical device type such as a pacemaker with detection of anodal stimulation by analysis of a vectogram

An implantable cardiac prosthesis device conducting an analysis of a patient tolerance to a pacing mode favoring the spontaneous atrioventricular conduction is disclosed. The device operates in a dual chamber (DDD or biventricular) mode and in a pacing mode favoring the spontaneous atrioventricular conduction such as an AAI mode () with a ventricular sensing or a mode with hysteresis of the atrioventricular delay. The device controls (-) the conditional switching from one mode to the other. The device comprises a hemodynamic sensor, including an endocardial acceleration sensor, derives a hemodynamic index representative of the hemodynamic tolerance of the patient to the spontaneous atrioventricular conduction. The device controls inhibiting or () forcing the conditional switching of the device to the DDD (or biventricular) mode according to the evolution of the hemodynamic index.

Apparatus and method for analyzing patient tolerance to a stimulation mode favoring a spontaneous atrioventricular conduction

An active implantable medical device of the defibrillator, cardiovertor and/or antitachycardia pacemaker type having a high maximum frequency for antibradycardia stimulation. This device provides antibradycardia stimulation at a stimulation frequency that has a programmed maximum stimulation frequency. For a detected rate exceeding a given frequency threshold, the device analyzes the cardiac activity to discriminate a ventricular tachycardia or fibrillation to command in consequence an appropriate antitachycardia therapy. The maximum stimulation frequency for antibradycardia is higher than the given frequency threshold for the antitachycardia analysis, and the cardiac rhythm is analyzed to detect a particular succession of events that are likely to reveal the presence or the appearance of a ventricular tachycardia during such high antibradycardia stimulation. In this case, the duration of the ventriculo-atrial delay of stimulation is prolonged at least until the end of the calculated escape interval, and until the end of the programmed maximum interval of detection of ventricular tachycardia. This accommodates an antibradycardia stimulation at a rate greater than the frequency threshold used to suspect or declare an antitachycardia while enabling detection of the latter.

Active implantable medical device of the defibrillator, cardiovertor and/or antitachycardia pacemaker type, having a high maximum frequency for antibradycardia stimulation

A process for managing medical data in an active implantable medical device such as a pacemaker, defibrillator, cardiometer or multisite device for use of the medical data by a specialized follow-up practitioner such as a cardiologist. The process is characterized by reading by telemetry the memory data () of the device () in a patient by use of a programmer (), memorizing in a database within the programmer the raw medical data thus read, the database having a memory field () containing an identifier of the patient (), an address () of the follow-up practitioner such as a cardiologist or a regular practitioner ensuring the medical follow-up of the patient, as well as the aforementioned raw medical data (), transmitting by a telematic way () to that follow-up practitioner, at the corresponding address, the medical data relating to the identified patient, and collecting, treating and presenting to the follow-up practitioner the medical data thus transmitted. A dedicated software () implemented on a microcomputer () at the disposal of the follow-up practitioner is used for the collection of the raw data and its treatment, processing and display for use by the follow-up practitioner.

Managing medical data of an active implantable device such as a pacemaker, defibrillator, cardiovertor and/or multisite device for a cardiologist

A process for the presentation of data stored in an active implantable medical device to assist a practitioner in making a diagnosis. This process includes the steps of: a) reading the raw implant data in the stored memory of the device, b) processing the raw data to elaborate a synthesis of the data, preferably through the use of an expert system, c) indexing the elaborated data synthesis according to a plurality of headings, each heading having associated therewith a set of specific implant data having contributed to the development of the heading, d) displaying on a screen (), at the destination of a user, the aforementioned headings, in the form of a plurality of distinct display fields () grouped on the same summary page (), e) putting at the disposal of the user a tool for the individual selection of each one of the plurality of fields, and f) when a field of the summary page is selected at the choice of the user, displaying on the summary page () the aforementioned specific implant data () having contributed to the development of the heading corresponding to this selected field ().

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Thouaré sur Loire, France

Laurence Graindorge