Washington University

University of California

Harvard College

The Broad Institute, Inc.

Laurence David Sibley

Qiuling Wang

Iti Saraav

Kevin M Brown

Kevan M Shokat

James Walter Janetka

Eamon Comer

Bruno Melillo

Florentine Rutaganira

Mary Savari Dhason

Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including cryptosporidiosis.

Compounds and methods for the treatment of parasitic diseases

Antigens ofthat provide specific and strong delayed type hypersensitivity (DTH) immune response, or which stimulate IFN-γ secretion, are used for testing subjects for infection. Any skin testing format may be adapted for testing for the delayed type hypersensitivity, including a patch, a needle, or a prong. Presence of DTH indicates infection. Alternate methods of detecting a T cell response including monitoring IFN-γ secretion may be used.

Antigens for detecting toxoplasma infection by monitoring cellular immunity

proteins MIC1 and MIC4 are components of excretory/secretory antigens (ESA) that elicit delayed type hypersensitivity (DTH) responses in infected animals. These antigens are capable of inducing IFN-g secretion by splenic T cells (ELISPOT assay), stimulating T cells to produce cytokines that recruit inflammatory monocytes and neutrophils resulting in a positive luminol test (luminol ear assay), and eliciting a positive skin test in the guinea pig.

Immunologically active fragments of toxoplasma gondii

Antigens ofthat provide specific and strong delayed type hypersensitivity (DTH) immune response, or which stimulate IFN-y secretion, are used for testing subjects for infection. Any skin testing format may be adapted for testing for the delayed type hypersensitivity, including a patch, a needle, or a prong. Presence of DTH indicates infection. Alternate methods of detecting a T cell response including monitoring IFN-y secretion may be used.

Disclosed herein, inter alia, are compositions and methods for treating parasitic diseases.

Growing community of inventors

St. Louis, MO, United States of America

Laurence David Sibley