The United States of America, as Represented by the Secretary, Department of Health and Human Services

Baylor College of Medicine

Lauren V Wood

Jay A Berzofsky

Masaki Terabe

Brenda D Roberson

Malcolm K Brenner

Jason C Steel

John C Morris

Masaki R Terabe

Recombinant adenoviruses expressing the extracellular (EC) and transmembrane (TM) domains of human HER2 (HER2ECTM) are described. The recombinant adenoviruses express a chimeric fiber protein having the adenovirus type 35 (Ad5) shaft and knob domains, which facilitates transduction of human dendritic cells by the recombinant HER2ECTM expressing adenovirus. Compositions that include dendritic cells transduced by the recombinant adenovirus and their use for treating HER-positive tumors is described.

Compositions and methods for the treatment of HER2-expressing solid tumors

Immunogenic T cell receptor &#x3b3; alternate reading frame protein (TARP) peptide compositions that include multiple epitopes of the TARP protein are described. The disclosed compositions can be used for the treatment of TARP-expressing cancers, such as prostate cancer, breast cancer and mesothelioma. In some embodiments, the TARP peptide compositions disclosed herein include sets of overlapping TARP peptides that each have a length of about 15 to about 25 amino acids, and comprise about 5 to about 15 amino acids that are identical to at least another overlapping peptide in the set. In particular examples, the combination of the overlapping TARP peptides in the set encompasses the complete amino acid sequence of human TARP. The multi-epitope peptide compositions described herein include both CD4 and CD8 epitopes, a feature that is important for eliciting CD4T cell and CD8T cell, as well as humoral, immune responses.

Multi-epitope TARP peptide vaccine and uses thereof

Growing community of inventors

Bethesda, MD, United States of America

Lauren V Wood