University of California

Pfizer Corporation

Leland Stanford Junior University

Lauren K Ely

Jeffrey A Bluestone

Isaac J Rondon

Natasha K Crellin

Eleonora Trotta

Kenan Christopher Garcia

Paul Henry Bessette

Shaun R Coughlin

Yun Cheol Kim

Qizhi Tang

Tovo David

Huilan Gao

Thomas Mikita

Jason Robles Reyes

Chia Chi Ho

The invention provides LFA3 polypeptide molecules, e.g., variant LFA3 fusion polypeptide molecules. The invention includes uses, and associated methods of using the LFA3 polypeptide molecules.

Lymphocyte function-associated antigen 3 (LFA3) variant polypeptides and methods of use thereof to treat CD2-mediated immune diseases, disorders or conditions

The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2R&#x3b1; and IL-2R&#x3b2;. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.

Anti-IL-2 antibodies and compositions and uses thereof

In one aspect, antibodies, or antigen-binding fragments thereof, that specifically bind to activated Factor XI (FXIa) are provided. Also provided are methods of obtaining such antibodies and nucleic acids encoding the same. In another aspect, compositions and therapeutic prevention of thrombotic diseases, disorders or conditions are provided. In another aspect, anti-idiotype antibodies that bind anti-FXIa antibodies of the disclosure, as well as compositions comprising the anti-idiotype antibodies, methods of obtaining the antibodies and nucleic acids encoding the same, are also provided.

Antibodies to coagulation factor XIa and uses thereof

Growing community of inventors

Palo Alto, CA, United States of America

Lauren K Ely