Ut-battelle, Inc.

University of Georgia Research Foundation, Inc.

University of Tennessee Research Foundation

Lauren A Riley

Adam Michael Guss

Janet Westpheling

This disclosure describes recombinantmicrobes designed to include increased consumption of acetate, increased carbon flux to butyryl-CoA and/or hexanoyl-CoA, increased production of butyrate and/or hexanoate, or a combination thereof, than a comparable control. This disclosure also describes methods that generally include growing such recombinant microbes under conditions effective for the recombinant microbes to consume greater amounts of acetate, produce increased amounts of butyryl-CoA and/or hexanoyl-CoA, produce increased amounts of butyrate and/or hexanoate, or a combination thereof.

Microbial approach for the production of long chain compounds

This disclosure provides a genetically-modified bacterium from the genusthat comprises an exogenous nucleic acid encoding a bifunctional aldehyde/alcohol dehydrogenase that produces butanol as the final product. The disclosure further provides methods for producing butanol using such genetically-modified bacterium.

Growing community of inventors

Lakewood, CO, United States of America

Lauren A Riley