Howard Hughes Medical Institute

Laurel M Heckman

Jonathan B Grimm

Eric R Schreiter

Luke D Lavis

The presently-disclosed subject matter relates to analyte-activated photolabile compounds. The compounds include the formula: wherein Z includes a maskable molecule; L is selected from a bond, C, C(O), O, alkyl, (O)alkyl, and alkoxy; Ris selected from H, halogen, alkyl, and acyl; each Ris independently selected from H, alkyl, aryl, and acyl, and is optionally substituted with one or more heteroatoms independently selected from COOH and COO(alkyl); and Ris selected from H, alkyl, aryl, halogen, CN, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, CHO, COOH, COO(alkyl), COO(aryl), POH, and SOH, and is optionally substituted with one or more heteroatoms independently selected from N, O, and S, halogen, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, NO, CHO, COO, COOH, COO(alkyl), COO(aryl), C(O)NR, POH, and/or SOH. Also provided are methods of detecting calcium and treating a subject with the analyte-activated photolabile compounds.

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Ashburn, VA, United States of America

Laurel M Heckman