Evolva Sa

River Stone Biotech LLC

Laura Tatjer Recorda

Veronique Douchin

Esben Halkjaer Hansen

Kim Olsson

Joseph M Sheridan

Philipp Friedrich Berninger

Markus Schwab

Jon Richard Heal

Joseph Michael Sheridan

Angela Manuela Ribeiro De Carvalho

Christian Nyffengger

Rubini Maya Kannangara

Sumire Honda Malca

The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-demethylated and/or O-demethylated reticuline and/or derivatives thereof, comprising cultivating the recombinant host of the invention in a culture medium under conditions in which the one or more genes encoding the cytochrome P450 enzymes is/are expressed. The reticuline and derivatives thereof are useful for providing access to naturally unavailable and chemically difficult-to-produce starting materials for opioids.

Demethylation of reticuline and derivatives thereof with fungal cytochrome P450

The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosides of steviol precursors, and steviol glycoside precursors.

Production of steviol glycosides in recombinant hosts

Growing community of inventors

Copenhagen, Denmark

Laura Tatjer Recorda