Biogen Idec Ma Inc.

Sunesis Pharmaceuticals, Inc.

Biogen Ma Inc.

Daniel H. S. Lee

Ellen A. Garber

Jane K. Relton

Xinzhong Wang

Paul H. Weinreb

Dingyi Wen

Alexey Lugovskoy

R. Blake Pepinsky

Laura Silvian

Werner Meier

Alexey Alexandrovich Lugovskoy

R Blake Pepinsky

Gnanasambandam Kumaravel

Min Zhong

Deping Wang

Brian T Hopkins

Junfa Fan

Patrick R Conlon

Daniel M Scott

Tracy J Jenkins

Daniel A Erlanson

Bing Guan

Noel Aaron Powell

Minna Bui

Julio Hernan Cuervo

Art Taveras

Doug Marcotte

Anthony Rossomando

Dinah Wen-Yee Sah

Ellen A Garber

Paula Ann Boriack-Sjodin

Paul H Weinreb

Daniel H S Lee

Jane K Relton

Stephan S Miller

Daniel Hs Lee

Daniel HS Lee

The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.

Bruton's tyrosine kinase inhibitors

Bruton'S tyrosine kinase inhibitors

Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

Nogo receptor antagonists and methods of increasing neurite outgrowth

Nogo receptor antagonists

Compositions and methods for folding proteins belonging to the transforming growth factor beta superfamily are disclosed. The compositions and methods allow for the folding of such proteins when produced in an expression system that does not yield a properly folded, biologically active product.

Neublastin variants

A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.

Polymer conjugates of mutated neublastin

Growing community of inventors

Waban, MA, United States of America

Laura Silvian