Zambon Group S.p.a.

Imperial College Innovations Limited

Universitá Degli Studi Di Milano-Bicocca

Zamon Group S.p.a.

Laura Russo

Marco Villa

Graziano Castaldi

Pietro Allegrini

Claudio Giordano

Giuseppe Barreca

Dario Tentorio

Gaetano Marchioro

Claudio Pozzoli

Laura Francesca Cipolla

Francesca Tallia

Gloria Ruth Young

Julian Raymond Jones

The invention relates to inorganic-organic hybrid materials comprising interpenetrated organic and inorganic components, wherein the organic component comprises polymer chains formed at least in part by ring-opening polymerization of a cyclic monomer, and processes for the production thereof.

Hybrid materials and process for production thereof

A process which allows the re-use of compounds of formula ##STR1## in diltiazem synthesis through a process of conversion to a mixture of enantiomers III-(2R,3R) and III-(2S,3S) is described.

Process for the recycle of a waste product of diltiazem synthesis

A process for the preparation of 5-amino-2,4,6-triiodoisophthalic acid dichloride by chlorination of 5-amino-2,4,6-triiodoisophthalic acid with thionyl chloride in the presence of a suitable solvent characterized in that the reaction is carried out in the presence of catalytic amounts of a tetraalkylammonium salt of formula

Process for the preparation of 5-amino-2,4,6-Triiodoisophthalic acid

A purification method of intermediates for the preparation of Diltiazem which consists of the crystallization of a mixture enantiomerically enriched in (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H) -one is described.

Process for the single crystallization of enatiomeric ratio's

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Milan, Italy

Laura Russo