Merck Sharp + Dohme Corp.

Laura Orsatti

Yan Li

Pingyu Zhong

Feng Dong

Holly A Hammond

Rose M Cubbon

Ayesha Sitlani

Kevin Caili Wang

Jeffrey T Blue

Jon H Condra

Shilpa Pandit

Laurence B Peterson

Joseph C Santoro

Denise K Nawrocki

Dana D Wood

Henryk Mach

Sonia M Gregory

Peter Peizhi Luo

Heidi Pixley

Heidi Yoder

Peizhi (Peter) Luo

Antagonists of human proprotein convertase subtilisin-kexin type 9 ('PCSK9') are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.

1D05 PCSK9 antagonists

Growing community of inventors

Ponezia, Italy

Laura Orsatti